| Are There Challenges in the Interpretation of Head and Neck Specimens? | p. ix |
| The Lichenoid Tissue Reactions of the Oral Mucosa: Oral Lichen Planus and Other Lichenoid Lesions | p. 1005 |
| Lichenoid changes in the oral mucosa can be encountered in a wide range of lesions and can have varied etiologies. Immune-mediated disorders, including lichen planus, mucous membrane pemphigoid, discoid lupus erythematosus, and graft-versus-host disease, can have clinical and histologic overlaps. Lichenoid reactions to dental materials, such as amalgam, or to many systemic drugs are also well documented. Dysplasia of the oral cavity at times can also express a lichenoid histology, which may mask the potentially cancerous component. Proliferative verrucous leukoplakia, an unusual clinical disease, mimics oral lichen planus clinically and requires careful correlation of the clinical and pathologic features. | |
| Odontogenic Cysts and Tumors | p. 1027 |
| This article presents various odontogenic cysts and tumors, including periapical cysts, dentigerous cysts, odontogenic keratocysts, orthokeratinized odontogenic ,v cysts, lateral periodontal cysts, glandular odontogenic cysts, ameloblastomas, clear cell odontogenic carcinomas, adenomatoid odontogenic tumors, calcifying epithelial odontogenic tumors, squamous odontogenic tumors, ameloblastic fibromas, ameloblastic fibro-odontomas, odontomas, calcifying cystic odontogenic tumors, and odontogenic myxomas. The authors provide an overview of these cysts and tumors, with microsopic features, gross features, differential diagnosis, prognosis, and potential diagnostic pitfalls. | |
| Select Neoplasms of the Sinonasal Tract | p. 1093 |
| The sinonasal tract (SNT) includes the nasal cavity and paranasal sinuses (maxillary, ethmoid, frontal, and sphenoid) and may give rise to a variety of nonneoplastic and neoplastic proliferations, including benign and malignant neoplasms. The benign neoplasms of the SNT include epithelial neoplasms of surface epithelial origin, minor salivary gland origin, and mesenchymal origin. The spectrum of malignant neoplasms of the SNT includes epithelial malignancies, sinonasal undifferentiated carcinoma, malignant salivary gland neoplasms, neuroectodermal neoplasms, neuroendocrine neoplasms, melanocyte neoplasm, and sarcomas. This article concentrates on some of the more common types of benign and malignant neoplasms. | |
| Squamous Cell Carcinoma of the Oral Cavity and Oropharynx | p. 1127 |
| The most common malignancy to involve the oral cavity and oropharynx is squamous cell carcinoma (SCC). Because these oral cancers share an origin from the squamous epithelium, the pathology of oral SCC might be expected to be uniform and its diagnosis repetitive. In reality, the morphologic diversity in SCC, along with the propensity for reactive processes of the oral cavity to mimic SCC histologically, renders its diagnosis one of the more challenging in surgical pathology. This article discusses variants of oral and oropharyngeal SCC and highlights those features that help distinguish human papillomavirus-related from human papillomavirus-unrelated SCC. | |
| Common Lesions of the Larynx and Hypopharynx | p. 1153 |
| Benign and malignant lesions of the larynx and hypopharynx present an interesting and diverse spectrum of diagnostic entities, which may be infrequently encountered in routine surgical pathology practice. This article places emphasis on illustrating the classical pathologic characteristics, differential diagnosis, clinical significance, and presentation of common lesions unique to these sites. The initial diagnosis of these lesions is via small endoscopic biopsy. Many of the entities have overlapping histologic features which necessitate optimizing the information available in a small sample. The focus of this article is to provide useful criteria to enable separating the more common types of lesions encountered in these sites. | |
| Common Malignant Salivary Gland Epithelial Tumors | p. 1177 |
| Malignant salivary gland epithelial tumors are histologically diverse with at least 24 recognized distinct entities. In general, malignant tumors account for 15% to 30% of parotid tumors, 40% to 45% of submandibular tumors, 70% to 90% of sublingual tumors, and 50% of minor salivary tumors. Common malignancies include mucoepidermoid carcinoma, adenoid cystic carcinoma, acinic cell carcinoma, salivary duct carcinoma, carcinoma ex pleomorphic adenoma, polymorphous lowgrade adenocarcinoma, and myoepithelial carcinoma. Each tumor type has its own unique histologic variants and prognostic pathologic features, and only mucoepidermoid carcinomas have a formalized grading system. The molecular pathogenesis of certain tumors, such as mucoepidermoid carcinoma and adenoid cystic carcinoma, has recently begun to be elucidated. | |
| Rare Malignant and Benign Salivary Gland Epithelial Tumors | p. 1217 |
| Although at least 24 distinct histologic salivary gland carcinomas exist, many of them are rare, comprising only 1 % to 2% of all salivary gland tumors. These include epithelial-myoepithelial carcinoma, (hyalinizing) clear cell carcinoma, basal cell adenocarcinoma, cystadenocarcinoma, low-grade salivary duct carcinoma (low-grade cribriform cystadenocarcinoma), oncocytic carcinoma, and adenocarcinoma not otherwise specified. Few tumors (clear cell carcinoma and basal cell adenocarcinoma) have unique molecular correlates. Benign tumors, although histologically less diverse, are far more common, with pleomorphic adenoma and Warthin tumor the most common salivary gland tumors. Many benign tumors have malignant counterparts for which histologic distinction can pose diagnostic challenge. | |
| Bone Lesions of the Head and Neck | p. 1273 |
| This article describes the clinical, radiographic, and pathologic features of tumors and tumorlike lesions affecting the bones of the head and neck region. Emphasis is placed on common bone lesions affecting the craniofacial skeleton, -particularly those that occur with more frequency or those that are unique to this part of the skeleton. Several of these lesions pose a diagnostic challenge to the pathologist. To ensure that a correct diagnosis is rendered, it is of utmost importance that accurate k and detailed clinical and radiographic information is available. | |
| Index | p. 1329 |
| Table of Contents provided by Ingram. All Rights Reserved. |
