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Cox-2 Blockade in Cancer Prevention and Therapy : Cancer Drug Discovery & Development - Randall E. Harris

Cox-2 Blockade in Cancer Prevention and Therapy

Cancer Drug Discovery & Development

By: Randall E. Harris (Editor)

Hardcover Published: 3rd October 2002
ISBN: 9781588290106
Number Of Pages: 371

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The revelation that aspirin and aspirin-like compounds have notableantineo­ plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op­ portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma­ ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly­ unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen­ esis, cell division, angiogenesis, cell differentiation, and apoptosis.

Industry Reviews

..".a must, not only for oncologists but also for every family doctor, who is often the first to see a patient with a cancerous or precancerous or precancerous condition." -Lancet Oncology

"This comprehensive and up-to-date monograph demonstrates how COX-2 inhibitors and other NSaids reduce the risk of most cancers and provides cancer investigators by a clear and authoritative guide leading to the development of novel angst with significant antineoplastic properties." -Neoplasma

Prefacep. v
Contributorsp. ix
Historical Perspectives
Dietary Fatty Acids, COX-2 Blockade, and Carcinogenesisp. 3
Historical Aspects of COX-2: Cloning and Characterization of the cDNA, Protein and Genep. 13
Epidemiology of NSAIDs and Cancer
Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancerp. 35
Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancerp. 57
Animal Models of Carcinogenesis
Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Preventionp. 71
Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animalsp. 85
The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancerp. 99
Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesisp. 117
Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugsp. 147
Molecular Biology of COX-2
Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesisp. 159
Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2p. 171
Cyclooxygenase-2 and Cancerp. 185
Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cellsp. 205
Association of COX-2 and PPARs in Carcinogenesis and Chemopreventionp. 225
Carcinogenesis Involving Cyclooxygenase and Lipoxygenasep. 245
Clinical Applications
The Development of Drugs that Target Cyclooxygenase-2p. 259
Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockadep. 279
Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponsep. 301
Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapyp. 313
Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impactp. 341
Indexp. 367
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9781588290106
ISBN-10: 1588290107
Series: Cancer Drug Discovery & Development
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 371
Published: 3rd October 2002
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 2.24
Weight (kg): 0.89