| Population Dynamics During Cell Proliferation and Neuronogenesis in the Developing Murine Neocortex | |
| References | p. 22 |
| Mechanisms Regulating Lineage Diversity During Mammalian Cerebral Cortical Neurogenesis and Gliogenesis | |
| Stem Cell Biology and Neural Development | p. 27 |
| Neural Lineage Elaboration and Bone Morphogenetic Proteins | p. 30 |
| Environmental and Transcriptional Regulation of Intermediate Progenitor Species | p. 33 |
| Mechanisms Regulating Neuronal and Astroglial Lineage Elaboration | p. 35 |
| Developmental Regulation and Lineage Potential of Radial Glia | p. 36 |
| Biology of Glial-Restricted Progenitors and the Generation of Oligodendrocytes | p. 37 |
| Role of ID Genes and Proteins in BMP-Mediated Cerebral Cortical Neural Fate Decisions | p. 38 |
| ID Genes and Proteins | p. 40 |
| Regulatory Roles | p. 40 |
| Nervous System Functions | p. 41 |
| Summary and Future Directions | p. 43 |
| References | p. 44 |
| Gap Junctions and Their Implications for Neurogenesis and Maturation of Synaptic Circuitry in the Developing Neocortex | |
| Introduction | p. 53 |
| Survey of Neocortical Development | p. 54 |
| Neurogenesis, Migration and Development of Afferents | p. 55 |
| Development of Functional Synapses | p. 57 |
| Expression of Gap Junctions in the Neocortex | p. 61 |
| Expression During the Embryonic Development of the Neocortex | p. 61 |
| Expression During the Early Postnatal Development of the Neocortex | p. 62 |
| Modulation of Gap Junction Permeability During Early Postnatal Stages of Neocortical Development | p. 64 |
| Functional Implications of Gap Junctions in the Developing Neocortex | p. 64 |
| Neurogenesis | p. 65 |
| Development of Intrinsic Neuronal Properties | p. 67 |
| Domains, Calcium Oscillations and Circuit Formation | p. 67 |
| Electrical Coupling of Inhibitory Interneurons | p. 68 |
| Concluding Remarks | p. 69 |
| References | p. 70 |
| Influence of Radial Glia and Cajal-Retzius Cells in Neuronal Migration | |
| Radial Glial Cells | p. 75 |
| Cajal-Retzius Cells and Reelin | p. 76 |
| MAM Model | p. 79 |
| What Prevents the Normal Laminar Pattern in E24 MAM-Treated Cortex? | p. 82 |
| Is There a Radialization Factor in Normal P0 Cortex? | p. 84 |
| Summary and Conclusions | p. 85 |
| References | p. 87 |
| Neurotrophins and Cortical Development | |
| Introduction | p. 89 |
| Distribution of the Neurotrophins and Their Receptors | p. 91 |
| Regulation of the Neurotrophins by Activity | p. 93 |
| Effects of Activity on Neurotrophin Secretion | p. 94 |
| Regulation of Synaptic Plasticity by the Neurotrophins | p. 95 |
| Acute Effects on Synaptic Function | p. 95 |
| Long-Term Potentiation and Depression | p. 96 |
| Neurotrophins and Structural Synaptic Plasticity | p. 97 |
| Axonal Growth | p. 98 |
| Dendritic Growth | p. 99 |
| Synapse Formation and Maintenance | p. 101 |
| Activity-Dependent Plasticity | p. 102 |
| Concluding Remarks | p. 103 |
| References | p. 104 |
| Role of Immediate Early Gene Expression in Cortical Morphogenesis and Plasticity | |
| Neural Activity Plays a Critical Role in the Development of the Cerebral Cortex | p. 113 |
| Learning and Development Share Mechanisms of Neural Plasticity | p. 115 |
| Molecular Events Underlying Cortical Plasticity: the Immediate Early Gene Response | p. 116 |
| Effector Neuronal Immediate Early Genes | p. 119 |
| Growth Factors: Activin and BDNF | p. 119 |
| Extracellular Matrix and Signaling Molecules: Arcadlin, tPA, and Narp | p. 121 |
| Cytoskeletal Molecules: Arc | p. 124 |
| Signaling Molecules: Rheb and COX-2 | p. 125 |
| Anchoring/Coupling Proteins: Homer | p. 127 |
| Conclusions | p. 129 |
| References | p. 130 |
| Role of Afferent Activity in the Development of Cortical Specification | |
| Introduction | p. 139 |
| Sensory Modalities: Vision and Audition | p. 140 |
| Visual Processing | p. 140 |
| Auditory Processing | p. 143 |
| Vision Versus Audition | p. 144 |
| Intrinsic Determination of Modality-Specific Subregions of Cortex | p. 144 |
| A Role for Extrinsic Inputs in Specification of Local Cortical Networks | p. 145 |
| Theoretical Considerations for Experimentally Altering Cortical Inputs | p. 145 |
| The Rewiring Paradigm | p. 146 |
| Innervation of the Denervated MGN by the Retina | p. 148 |
| Physiological Consequences of Rewiring | p. 148 |
| Analyses of Rewired A1 | p. 149 |
| Receptive Field Mapping | p. 149 |
| Optical Imaging of Intrinsic Signals | p. 150 |
| Local Connections Within A1 | p. 150 |
| Other Signaling Mechanisms | p. 151 |
| Behavior and Effects Downstream of Primary Sensory Cortical Areas | p. 151 |
| Strategy to Identify and Characterize Cortical Genes Activated by Modality-Specific Inputs | p. 152 |
| References | p. 154 |
| Regional Forebrain Patterning and Neural Subtype Specification: Implications for Cerebral Cortical Functional Connectivity and the Pathogenesis of Neurodegenerative Diseases | |
| Introduction | p. 157 |
| Role of the Ventral Telencephalon in Cerebral Cortical Development | p. 159 |
| Developmental Actions of Neurogenic bHLH Genes | p. 161 |
| Mechanisms Regulating the Transition from Neurogenesis to Gliogenesis | p. 162 |
| Olig Genes and Regional Shh Signaling | p. 163 |
| Importance of Regional Forebrain Patterning for Neural Subtype Specification | p. 165 |
| Role of Local BMP Signaling in Cerebral Cortical Neuronal and OL Lineage Elaboration | p. 167 |
| Generation of OL Lineage Species in the Adult Brain: Therapeutic Implications | p. 168 |
| Role of Gap Junction Channels and GABAergic Neuronal Subtypes in Cerebral Cortical Functional Connectivity | p. 169 |
| Regional Forebrain Patterning and Neurodegenerative Diseases | p. 170 |
| Summary and Future Directions | p. 172 |
| References | p. 174 |
| Subject Index | p. 179 |
| Table of Contents provided by Publisher. All Rights Reserved. |
