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Cooperation of Liver Cells in Health and Disease : Advances in Spatial Sciences (Paperback) - Zbigniew Kmiec

Cooperation of Liver Cells in Health and Disease

Advances in Spatial Sciences (Paperback)

Paperback ISBN: 9783540418870
Number Of Pages: 151

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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Introduction - Morphology of the Liver Lobulep. 1
Cells of the Liver Lobulep. 7
Hepatocytesp. 9
Sinusoidal Endothelial Cellsp. 13
Kupffer Cellsp. 21
Hepatic Stellate Cellsp. 29
Pit Cells and Other Intrahepatic Lymphocytesp. 41
Cross-Talk of Liver Cells in Physiology and Pathologyp. 47
Cooperation of Liver Cells in the Synthesis and Degradation of Eicosanoidsp. 51
Nitric Oxide as a Mediator of Intercellular Communication in the Liverp. 61
Cooperation of Hepatocytes and Stellate Cells in the Metabolism and Storage of Retinoidsp. 65
Cooperation of Liver Cells in the Regulation of Glucose Metabolismp. 69
Cooperation of Liver Cells in the Synthesis of Growth Factors and Respective Binding Proteinsp. 73
Cooperation of Liver Cells in the Regulation of Sinusoidal Contractilityp. 79
Cross-Talk of Liver Cells in Response to Endotoxinp. 83
Cooperation of Liver Cells in the Process of Liver Fibrosisp. 97
Perspectivesp. 107
Summaryp. 109
Referencesp. 115
Subject Indexp. 149
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540418870
ISBN-10: 3540418873
Series: Advances in Spatial Sciences (Paperback)
Audience: General
Format: Paperback
Language: English
Number Of Pages: 151
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 22.86 x 15.24  x 1.27
Weight (kg): 0.24