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Controlled Drug Delivery : Designing Technologies for the Future - Kinam Park

Controlled Drug Delivery

Designing Technologies for the Future

Hardcover Published: 14th April 2000
ISBN: 9780841236257
Number Of Pages: 474

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Despite the public desire for a magic bullet--a drug that cures the ailment and is easy to take--most drugs require a sustained release to the target area as opposed to a burst, hence the need for controlled release devices. This volume devotes separate sections to current work in each of the key aspects for developing these devices, including the route of administration, drug delivery vehicles, drug targeting, and modulated drug delivery.

Industry Reviews

"The book combines information on diversified subjects related to controlled drug delivery. Most of its 29 review-type chapters focus on parenteral delivery, a few deal with oral applications. Almost all of the chapters, written by well-known authors in the field, are nicely set up, easy to read,
and well structured. Overall, the book can serve as an introduction for individual industrial and academic scientists who are starting to work in the field. Covering numerous subjects, which have become extensive fields themselves, an interested or experienced reader is referred to more detailed
books on microparticulate systems, drug targeting, colloidal drug carriers or protein and peptide delivery." -- Dr. Wolfgang Fried, European Journal of Pharmaceutics and Biopharmaceutics, 47, 1999

Prefacep. xi
Controlled Drug Delivery: Present and Futurep. 2
Oral Delivery: Design Consideration and Challenges
Controlled-Release Oral Delivery Systemsp. 14
Safe Mucosal Penetration Enhancers: A Fiction? Polymers as Absorption Enhancers for Transmucosal Drug Deliveryp. 25
Prodrug Strategies to Improve the Oral Absorption of Peptides and Peptide Mimeticsp. 36
Designing Prodrugs for the hPEPT1 Transporterp. 46
Oral Delivery of Heparinp. 54
Hypoglycemic Effect of Insulin in Oil Preparation by Oral Administrationp. 65
Feasibility Assessment and Rapid Development of Oral Controlled Release Prototypesp. 69
The Effect of Adhesive Antioxidant Enzymes on Experimental Colitis in the Ratp. 78
Oral Dosage Forms with Controlled Release for Constant Plasma Drug Levelp. 90
Delivery Strategies
Solving Drug Delivery Problems with Liposomal Carriersp. 100
PEGylation: A Tool to Enhance Protein Deliveryp. 110
Polymeric Delivery Vehicles for Bone Growth Factorsp. 124
De Novo Design and Synthesis of a Small Globular Protein That Forms a Pore in Lipid Bilayersp. 139
Natural Pore Forming Proteins: Paneth Cell Cryptdinsp. 149
Growth Factor Delivery from Tissue Engineering Matrices: Inducing Angiogenesis to Enhance Transplanted Cell Engraftmentp. 157
Drug Targeting
Targeting Macromolecular Therapeutics to Specific Cell Organellesp. 168
Modified Liposome Formulations for Cytosolic Delivery of Macromoleculesp. 184
Molecular Targeting of Nuclear Transcriptional Regulatorsp. 193
Cell-Specific Targeting of Drugs and Genes with Glycosylated Liposomes: Comparison with Glycosylated Poly(amino acids)p. 201
Targeted Gene Delivery via the Folate Receptorp. 212
Latest Advances in the Understanding of Active-Specific Immunotherapy for Brain Tumorsp. 220
Modulated Drug Delivery Vehicles
Application of pH- and Temperature-Sensitive Polymers for Controlled Drug Release Devicep. 232
Characterization of Poly(2-ethylacrylic acid) for Use in Drug Deliveryp. 243
Synthesis and Characterization of Thermoreversible, Protein-Conjugating Polymers Based on N-Isopropylacrylamidep. 253
A Novel Composite Membrane for Temperature- and pH-Responsive Permeationp. 263
Glucose Monitoring via Reverse Iontophoresisp. 273
Delivery Vehicles for Hydrophobic Drugs
Self-Emulsifying Drug Delivery Formulations in the 21st Century: Challenges and Opportunitiesp. 284
Polymeric Micelles for the Delivery of Poorly Soluble Drugsp. 297
The Role of Plasma Lipoproteins as Carriers of Water-Insoluble Compounds: Biological and Physiological Consequencesp. 314
Polymeric Lipid Nanosphere Composed of Hemocompatible Phospholipid Polymers as Drug Carrierp. 324
Solubility Considerations and Design of Controlled Release Dosage Formsp. 335
Polymeric Drug Delivery Vehicles
Polymer Therapeutics into the 21st Centuryp. 350
Controlled Release from Ordered Microstructures Formed by Poloxamer Block Copolymersp. 364
Supramolecular-Structured Polymers for Drug Deliveryp. 375
Fentanyl-Loaded Poly(L-lactide-co-glycolide) Microspheres for Local Anesthesiap. 385
Ionically Cross-Linked Polyphosphazene Microspheresp. 395
Polysaccharide as a Drug-Coating Polymerp. 407
Preparation of Blood-Compatible Nanoparticles Bearing Phosphorylcholine Groupp. 417
Author Indexp. 429
Subject Indexp. 431
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780841236257
ISBN-10: 0841236259
Series: ACS Symposium
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 474
Published: 14th April 2000
Publisher: American Chemical Society
Country of Publication: US
Dimensions (cm): 23.47 x 16.1  x 2.62
Weight (kg): 0.69