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Control of Breathing and Its Modeling Perspective - Yoshiyuki Honda

Control of Breathing and Its Modeling Perspective

By: Yoshiyuki Honda (Editor)

Hardcover

Published: 31st January 1993
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The fifth Oxford Conference was held on September 17th-19th, 1991, at the Fuji Institute of Training in Japan -the first time that the meeting has taken place in the Asian area. The facts that only a relatively few Japanese had attended previous Oxford Conferences and that Japan is far from other regions with possible participants made the organizers anticipate a small attendance at the meeting. However, contrary to our expectations, 198 active members (72 foreign and 126 domestic participants) submitted 146 papers from 15 countries. This was far beyond our preliminary estimate and could have caused problems in providing accommodation for the participants and in programming their scientific presentations. These difficulties, however, were successfully overcome by using nearby hotels, by telecasting presentations into a second lecture room and by displaying a substantial number of poster presentations during the whole period of the meeting. The meeting had two types of sessions: regular and current topics. The first paper in each session represented a shon overview or introduction so as to make it easier for the audience to comprehend the problems at issue. Because of the large number of papers submitted, carefully selected speakers (mostly well-known scholars) made excellent presentations that were followed by lively discussions. In this way, the conference laid a foundation on which to base its continued scientific success.

Modelling Pioneer: Fred S. Grodins (1915-1989)p. 1
Respiratory Rhythm Genesis
Maintenance of the Respiratory Rhythm during Normoxia and Hypoxiap. 7
Raphe Magnus-Induced Inhibition of Medullary and Spinal Respiratory Activities in the Catp. 15
Cranial Nerve and Phrenic Respiratory Rhythmicity during Changes in Chemical Stimuli in the Anesthetized Ratp. 25
Possible Implication of N. Parabrachialis in Opioid-Mediated Respiratory Suppression Induced by Thin-Fiber Muscular Afferentsp. 33
Synaptic and Non-Synaptic Control of Membrane Potential Fluctuations in Bulbar Respiratory Neurons of Catsp. 43
Nonlinear Dynamics of a Model of the Central Respiratory Pattern Generatorp. 51
Phase-Dependent Transient Responses of Respiratory Motor Activities following Perturbation of the Cyclep. 57
Lower Lumbar and Sacral Projections of Caudal Medullary Expiratory Neurons in the Catp. 61
Reflex Control
Reflex Control of Respiratory Activity (Short Overview)p. 65
Acid Infusion Elicits Thromboxane-Mediated Cardio-Respiratory Effectsp. 71
Respiratory Effects of "Renzhong Xue" in Rabbitsp. 75
Effects of Hypercapnia on Nasal Reflex Responses Elicited by Nasal Insufflation of Isoflurane in Lightly-Anesthetized Humansp. 79
Electrophysiological and Anatomical Studies of the Second Order Neurons in the Reflex Pathway from Pulmonary Rapidly Adapting Receptors in the Catp. 83
Laryngeal Afferent Activity and its Role in the Control of Breathingp. 87
Peripheral Chemosensitivity
Short Overview: Carotid Body Activities in Manp. 91
Dynamical Analysis of the Ventilatory Response to Changes in PETO[subscript 2]: Separation of Central and Peripheral Effectsp. 99
Single Breath Tests of the Ventilatory Response to Carbon Dioxide: Experimental and Modelling Resultsp. 107
Ventilatory Responses to Respiratory and Acute Metabolic Acidosis in Manp. 115
Role of Cl[superscript -]-HCO[subscript 3][superscript -] Exchanger and Anion Channel in the Cat Carotid Body Functionp. 119
A Mathematical Model of the Ventilatory Response to a Period of Sustained Isocapnic Hypoxia in Humansp. 123
Carbon Dioxide - Essential Ingredient for in Vivo Carotid Body Chemotransductionp. 127
Central Chemosensitivity
Hypoxic Depression of Respirationp. 131
Identification of Closed-Loop Chemoreflex Dynamics Using Pseudorandom Stimulip. 137
Lack of Ventilatory Reaction to Endogenous and Exogenous Metabolic Brain-Stem Acidosisp. 143
Synchronization of Respiratory Rhythm with Mechanical Ventilation by Respiratory CO[subscript 2] Oscillations in Vagotomized Dogsp. 147
Factors Influencing Day to Day Variability of Human Ventilatory Sensitivity to Carbon Dioxidep. 151
Integrative and Behavioral Control
Respiratory-Associated Firing of Midbrain and Thalamic Neurons: Possible Relation to the Sensation of Dyspneap. 155
Where Is the Cortical Representation of the Diaphragm in Man?p. 163
Dyspnea and Respiratory Compensation Response to Resistive Loading in Elderly Humansp. 167
Redundancy Structures in Respiratory Controlp. 171
Chemical and Non-Chemical Contributions to Breathing in Man, Awake and Asleepp. 179
Does Sustained Hypoxia Have Biphasic Effects on the Sensation of Dyspnea?p. 183
Role of Neurochemicals and Hormones
Overview: Role of Neurochemicals and Hormonesp. 187
The Role of Endogenous Opioids in the Ventilatory Response to Sustained Respiratory Loadsp. 197
Significance of Excitatory and Inhibitory Neurochemicals in Hypoxic Chemotransmission of the Carotid Bodyp. 205
Role of Serotonin in Airway Patency: Physiological and Morphological Evidence for Serotoninergic Inputs to Laryngeal Inspiratory Motoneuronsp. 213
Effects of Testosterone on Hypoxic Ventilatory and Carotid Body Neural Responsivenessp. 221
Effect of Theophylline on Brain Acid-Base Status during Normoxia and Hypoxia in Humansp. 225
Mechanisms of Exercise Hyperpnea
Asymmetrical Transients of Cardiorespiratory Variables in Response to Ascending and Descending Ramp Forcings of Exercise Loadp. 229
Dynamic Asymmetries of Ventilation and Pulmonary Gas Exchange during On- and Off-Transients of Heavy Exercise in Humansp. 237
The Effect of Exercise Intensity and Duration on Ventilation during Recovery from Moderate and Heavy Exercisep. 245
On the Fractal Nature of Breath-by-Breath Variation in Ventilation during Dynamic Exercisep. 255
The Time Course of Mixed Venous Blood Gas Composition following Exercise Onsetp. 263
Humoral Aspects of the Ventilatory Reactions to Exercise by Flux Inhalation of Carbon Dioxidep. 267
Nonlinear Dynamics of Cardiopulmonary Responses during Exercisep. 271
Ventilatory Response at the Onset of Passive Exercise during Sleep in Manp. 275
Ventilatory Responses to Ascending and Descending Ramp Changes in Inspired CO[subscript 2]p. 279
Effect of Femoral Blood Flow Occlusion and Release on Ventilation during Exercise and Recoveryp. 283
Hypoxic Ventilatory Depression
Introduction: Depression of Ventilation by Hypoxia - A Comparison of the Phenomenon in Anaesthetized Cats and Conscious Humansp. 287
The Effects of Dopamine on the Ventilatory Response to Sustained Hypoxia in Humansp. 291
Effects of Varying End-Tidal PO[subscript 2] on Hypoxic Ventilatory Decline in Humansp. 299
Developmental Aspects of the Central Effects of Hypoxiap. 303
Modulation of Respiration by Brain Hypoxiap. 307
Respiratory Depression Following Acute Hypoxia in Vagotomized and Carotid Sinus Nerve Denervated Catsp. 311
Sleep Disorders
Respiratory and Postural Suppression by Stimulation of the Midpontine Dorsal Tegmentum in Decerebrate Catsp. 315
The Role of Ventral Group Neurons in the Respiratory Depression during Carbachol-Induced REM Sleep Atoniap. 323
Control of Breathing in COPD-Patients with Sleep Hypopnea: Effects of Acetazolamide and Chlormadinone Acetatep. 331
Serial Submental Stimulation during Sleep in Patients with Obstructive Sleep Apneap. 337
Mechanical Aspects in the Control of Breathing
Effects of Viscoelastic Properties of Respiratory System on Respiratory Dynamicsp. 341
Influence of Age on Ventilatory Pattern during Exercisep. 347
Abdominal Muscle Function with Change in Posture or CO[subscript 2] Rebreathing in Humansp. 351
Subacute Effects of Denervation on Rat Hemidiaphragmp. 355
Cellular and Molecular Aspects
[beta]-Endorphins-Based Inhibitory Component of the Mechanism of Ventilatory Response to Hypoxiap. 359
Phosphoinositides and Signal Transduction in the Cat Carotid Bodyp. 367
Optimization Hypothesis
Introduction: Optimization Hypothesis in the Control of Breathingp. 371
Effects of Changes in Ventilatory Pattern during Altitude Acclimatizationp. 385
Optimal Control Analysis of the Breathing Pattern by Using the WBREPAT Computer Softwarep. 393
A Model for the Contribution of Lung Receptors to the Control of Breathing: Positive and Negative Feed-Backsp. 397
New Results in System Identificationp. 401
Effects of Changes in Breathing Pattern on the Sensation of Dyspnea during Inspiratory Loaded Breathingp. 405
Role of Potassium Ion in Exercise Hyperpnea
Introduction: Role of Potassium in Exercise Hyperpnoeap. 409
Acid-Base Regulation and Ventilatory Control during Exercise and Recovery in Manp. 417
Influence of Body CO[subscript 2] Stores on Ventilatory-Metabolic Coupling during Exercisep. 425
Adaption of Peripheral Chemoreceptors
Respiration in Chronic Hypoxia and Hyperoxia: Role of Peripheral Chemoreceptorsp. 433
Carotid Body Chemotransductionp. 441
Altitude Acclimatization and Hypoxic Ventilatory Depression: Lowlanders and Highlandersp. 447
Serial Changes in Acute Hypoxic and Hypercapnic Ventilatory Responses during High Altitude Acclimatizationp. 451
Abnormal Breathing Pattern and Oxygen Desaturation during Sleep at High-Altitudep. 455
Indexp. 459
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306443008
ISBN-10: 0306443007
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 461
Published: 31st January 1993
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 3.18
Weight (kg): 2.47