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Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds : Volume 27 - J. Thomas August

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds

Volume 27

By: J. Thomas August (Editor), Ferid Murad (Editor), M.W. Anders (Editor), Wolfgang Dekant (Editor)

Hardcover Published: 1st May 1994
ISBN: 9780120329274
Number Of Pages: 519

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics.
This special volume of Advances in Pharmacology features a two-color dust jacket.
Key Features
* Summarizes the most recent information on:
* Xenobiotic conjugation
* Drug toxicity, hypersensitivity, and targeting
Chemical carcinogenesis
* Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity
* Bioactivation and bioconversion

Praise for the Serial "The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading." --JOURNAL OF PHARMACEUTICAL SCIENCES

Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds
Glutathione-Dependent Toxicity
Enzymology of Microsomal Glutathione S-Transferase
Enzymology of Cytosolic Glutathione S-Transferases
Enzymology of Cysteine S-Conjugate b-Lyases
Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway
Reversibility in Glutathione-Conjugate Formation
Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites
Metabolism and Genotoxicity of Dihaloalkanes
Bioactivation of Thiols by One-Electron Oxidation
Glutathione Mercaptides as Transport Forms of Metals
Sulfate Conjugate-Dependent Toxicity: Biochemistry of Cytosolic Sulfotransferases Involved in BioactivationC.N. Falany
Carcinogen Activation by Sulfate Conjugate Formation
Glucuronide Conjugate-Dependent Toxicity: UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens
Bioactivation of Glucuronide-Conjugate Formation
Bioactivation and Bioconversion: N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation
Bioconversion of Prodrugs by Conjugate-Processing Enzymes
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780120329274
ISBN-10: 0120329271
Series: Advances in Pharmacology : Book 27
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 519
Published: 1st May 1994
Country of Publication: US
Dimensions (cm): 22.91 x 15.19  x 3.02
Weight (kg): 0.88