The conjugation of ubiquitin and ubiquitin-like modifiers by activating enzymes (E1), conjugating enzymes (E2) and ligases (E3) has been a subject of intensive research in the past years. The complexity of the conjugation cascades with dozens of E2 enzymes and hundreds of E3 enzymes requires that emerging common principles are delineated. On the other hand the functional implications for each modifier need to be considered. In this book leading experts actively investigating the conjugation and deconjugation enzymes for ubiquitin, SUMO, NEDD8, ISG15 and FAT10 review the progress in the specific fields. Moreover, novel insights into the function of the respective modifiers are presented. This book should allow scientists from all areas of cell biology and molecular medicine as well as students and young scientists entering this field to get an introduction to ubiquitin modifier conjugation and to get an update on recent insights into this intensively investigated area of research.
Preface: New Paradigms in the Conjugation of Ubiquitin Family Modifiers xvii Marcus Groettrup 1. Activation of Ubiquitin and Ubiquitina'Like Proteins 1 Frederick C. Streich, Jr. and Arthur L. Haas 2. Control of Ubiquitin Conjugation by Cdc48 and Its Cofactors 17 Alexander Buchberger 3. Regulation of Ubiquitin Receptors by Coupled Monoubiquitination 31 Daniela Hoeller and Ivan Dikic 4. Control of Cullina'Ring Ubiquitin Ligase Activity by Nedd8 41 Raymond J. Deshaies, Ethan D. Emberley and Anjanabha Saha 5. Control of Deneddylation by the Cop9 Signalosome 57 Tilo Schmaler and Wolfgang Dubiel 6. Mechanism, Specificity and Structure of the Deubiquitinases 69 David Komander 7. Ubiquitin Conjugation and Deconjugation in NFa'kB Signaling 88 Michael Duwel, Kamyar Hadian and Daniel Krappmann 8. Functions of Linear Ubiquitin Chains in the NFa'kB Pathway: Linear Polyubiquitin in NFa'I B Signaling 100 Kazuhiro Iwai 9. Assembly of K11a'Linked Ubiquitin Chains by the Anaphasea'Promoting Complex 107 Michael Rape 10. Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53 116 Dimitris P. Xirodimas and Martin Scheffner 11. Ubiquitylation in the ERAD Pathway 136 Frederik Eisele, Antje Schafer and Dieter H. Wolf 12. Pupylation: A Signal for Proteasomal Degradation in Mycobacterium tuberculosis 149 Kristin E. Burns and K. Heran Darwin 13. sumo Control 158 Katharina Maderbock and Andrea Pichler 14. The In Vivo Functions of Desumoylating Enzymes 170 Tasneem Bawaa'Khalfe and Edward T.H. Yeh 15. Regulatory Functions of Ubiquitin and Sumo in DNA Repair Pathways 184 Stefan Jentsch and Stefan Muller 16. Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation 195 Maria Miteva, Kirstin Keusekotten, Kay Hofmann, Gerrit J.K. Praefcke and R. Jurgen Dohmen 17. In Vivo Functions of Isgylation 215 Klausa'Peter Knobeloch 18. Identification and Validation of ISG15 Target Proteins 228 Larissa A. Durfee and Jon M. Huibregtse 19. FAT 10: Activated by UBA6 and Functioning in Protein Degradation 238 Christiane Pelzer and Marcus Groettrup Index 247
Series: Subcellular Biochemistry : Book 54
Number Of Pages: 252
Published: 20th August 2010
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 24.77 x 16.51
Weight (kg): 0.54