This book provides an introduction to two important aspects of modern bioch- istry, molecular biology, and biophysics: computer simulation and data analysis. My aim is to introduce the tools that will enable students to learn and use some f- damental methods to construct quantitative models of biological mechanisms, both deterministicandwithsomeelementsofrandomness;tolearnhowconceptsofpr- ability can help to understand important features of DNA sequences; and to apply a useful set of statistical methods to analysis of experimental data. The availability of very capable but inexpensive personal computers and software makes it possible to do such work at a much higher level, but in a much easier way, than ever before. TheExecutiveSummaryofthein?uential2003reportfromtheNationalAcademy of Sciences, "BIO 2010: Transforming Undergraduate Education for Future - search Biologists" , begins The interplay of the recombinant DNA, instrumentation, and digital revolutions has p- foundly transformed biological research. The con?uence of these three innovations has led to important discoveries, such as the mapping of the human genome. How biologists design, perform, and analyze experiments is changing swiftly. Biological concepts and models are becoming more quantitative, and biological research has become critically dependent on concepts and methods drawn from other scienti?c disciplines. The connections between the biological sciences and the physical sciences, mathematics, and computer science are rapidly becoming deeper and more extensive.
From the reviews: "This book targets biochemistry and molecular biophysics students who have prior knowledge of a few subjects, including mathematics, statistics, and modeling, and possess very basic programming skills. Examples and illustrations are ample throughout the text, and the writing style is plain and efficient. ... this book mostly appropriate for students or researchers who have prior exposure to the related subjects. Summing Up: Recommended. Upper-division undergraduates through researchers/faculty." (D. Papamichail, Choice, Vol. 47 (5), January, 2010)
Part I: The Basics of R. Calculating with R. Plotting with R. Functions and Programming. Data and Packages.- Part II: Simulation of Biological Processes. Equilibrium and Steady State Calculations. Differential Equations and Reaction Kinetics. Population Models. Compartmental Models. Regulation of Metabolism. Regulation of Transcription and Development.- Part III: Analyzing DNA and Protein Sequences. Probability, Stochastic Processes, and Markov Chains. DNA Sequence Analysis.- Part IV: Statistical Analysis in Molecular Biology and Biophysics. Statistical Analysis of Data.- Microarrays.
Series: Biological and Medical Physics: Biomedical Engineering
Number Of Pages: 321
Published: 25th June 2009
Publisher: Springer-Verlag New York Inc.
Country of Publication: NL
Dimensions (cm): 23.37 x 15.49
Weight (kg): 0.61