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Computational Methods for Snps and Haplotype Inference : Dimacs/Recomb Satellite Workshop, Piscataway, NJ, USA, November 21-22, 2002, Revised Papers :  Dimacs/Recomb Satellite Workshop, Piscataway, NJ, USA, November 21-22, 2002, Revised Papers - Sorin Istrail

Computational Methods for Snps and Haplotype Inference : Dimacs/Recomb Satellite Workshop, Piscataway, NJ, USA, November 21-22, 2002, Revised Papers

Dimacs/Recomb Satellite Workshop, Piscataway, NJ, USA, November 21-22, 2002, Revised Papers

By: Sorin Istrail (Editor), Michael Waterman (Editor), Andrew Clark (Editor)

Paperback

Published: September 2008
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This book constitutes the post-proceedings of the DIMACS/RECOMB Satellite Workshop on Computational Methods for SNPs and Haplotype Inference held in Piscataway, NJ, USA, in November 2002.The book presents ten revised full papers as well as abstracts of the remaining workshop papers. All relevant current issues in computational methods for SNP and haplotype analysis and their applications to disease associations are addressed.

Trisomic phase inferencep. 1
An overview of combinatorial methods for haplotype inferencep. 9
A survey of computational methods for determining haplotypesp. 26
Haplotype inference and its application in linkage disequilibrium mappingp. 48
Inferring piecewise ancestral history from haploid sequencesp. 62
Haplotype blocks in small populationsp. 74
Simulating a coalescent process with recombination and ascertainmentp. 84
Dynamic programming algorithms for haplotype block partitioning and tag SNP selection using haplotype data or genotype datap. 96
Parametric bootstrap for assessment of goodness of fit of models for block haplotype structurep. 113
A coalescent-based approach for complex disease mappingp. 124
Haplotyping as perfect phylogenyp. 131
Exhaustive enumeration and bayesian phase inferencep. 132
How does choice of polymorphism influence estimation of LD and mapping?p. 133
Haplotype inference in random population samplesp. 134
Bayesian methods for statistical reconstruction of haplotypesp. 135
Combinatorial approaches to haplotype inferencep. 136
Large scale recovery of haplotypes from genotype data using imperfect phylogenyp. 137
Haplotype inference and haplotype informationp. 138
Multi-locus linkage disequilibrium and haplotype-based tests of associationp. 139
The pattern of polymorphism on human chromosome 21p. 140
Use of a local approximation to the ancestral recombination graph for fine mapping disease genesp. 141
Insights into recombination from patterns of linkage disequilibriump. 142
Joint bayesian estimation of mutation location and age using linkage disequilibriump. 143
Evolutionary-based association analysis using haplotype datap. 144
Inferring piecewise ancestral history from haploid sequencesp. 145
Testing for differences in haplotype frequencies in case-control studiesp. 146
Haplotypes, hotspots, and a multilocus model for linkage disequilibriump. 147
Dynamic programming algorithms for haplotype block partition and applications to association studiesp. 148
Genome sharing in small populationsp. 149
Patterns of linkage disequilibrium across human chromosomes 6, 21, and 22p. 150
A software system for automated and visual analysis of functionally annotated haplotypesp. 151
Assessment of goodness of fit of models for block haplotype structurep. 152
Author indexp. 153
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783540212492
ISBN-10: 3540212493
Series: Lecture Notes in Bioinformatics
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 158
Published: September 2008
Publisher: Springer-Verlag Berlin and Heidelberg Gmbh & Co. Kg
Country of Publication: DE
Dimensions (cm): 23.5 x 15.5  x 1.02
Weight (kg): 0.55
Edition Type: Annotated