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Computational Approaches in Molecular Radiation Biology : Monte Carlo Methods - Matesh N. Varma

Computational Approaches in Molecular Radiation Biology

Monte Carlo Methods

By: Matesh N. Varma (Editor), Aloke Chatterjee (Editor)

Hardcover Published: 28th February 1995
ISBN: 9780306449956
Number Of Pages: 264

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The Office of Health and Environmental Research (OHER) has supported and continues to support development of computational approaches in biology and medicine. OHER's Radiological and Chemical Physics Program initiated development of computational approaches to determine the effects produced by radiation of different quality (such as high energy electrons, protons, helium and other heavy ions, etc. ) in a variety of materials of biological interest-such as water, polymers and DNA; these include molecular excitations and sub-excitations and the production of ionization and their spatial and temporal distribution. In the past several years, significant advances have been made in computational methods for this purpose. In particular, codes based on Monte Carlo techniques have *been developed that provide a realistic description of track-structure produced by charged particles. In addition, the codes have become sufficiently sophisticated so that it is now possible to calculate the spatial and temporal distribution of energy deposition patterns in small volumes of subnanometer and nanometer dimensions. These dimensions or resolution levels are relevant for our understanding of mechanisms at the molecular level by which radiations affect biological systems. Since the Monte Carlo track structure codes for use in radiation chemistry and radiation biology are still in the developmental stage, a number of investigators have been exploring different strategies for improving these codes.

Computational Biology Opportunity and Challenges for the Futurep. 1
Overview of Significant Challenges in Molecular Biology Amenable to Computational Methodsp. 11
Basic Physical and Chemical Information Needed for Development of Monte Carlo Codesp. 21
Interactions of Low-Energy Electrons with Condensed Matter: Relevance for Track Structurep. 33
Electron Emission Resulting from Fast Ion Impact on Thin Metal Foils: Implications of These Data for Development of Track Structure Modelsp. 49
Direct Ionization of DNA in Solutionp. 65
Charged-Particle Transport in Biomolecular Media: The Third Generationp. 77
Track Structure, Chromosome Geometry, and Chromosome Aberrationsp. 93
Monte Carlo and Analytic Methods in the Transport of Electrons, Neutrons, and Alpha Particlesp. 115
PITS: A Code Set for Positive Ion Track Structurep. 137
Monte Carlo Track-Structure Calculations for Aqueous Solutions Containing Biomoleculesp. 155
Comparison of Various Monte Carlo Track Structure Codes for Energetic Electrons in Gaseous and Liquid Waterp. 167
A Comparison between Two Monte Carlo Codes on Determination of Transient Chemical Yieldsp. 187
An Attempt to Modify the MOCA Water-Vapor-Ion Code to Simulate Liquid Phasep. 195
Three Statistical Technologies with High Potential in Biological Imaging and Modelingp. 199
Monte Carlo Approach in Assessing Damage in Higher Order Structures of DNAp. 225
A Nucleosome Model for the Simulation of DNA Strand Break Experimentsp. 243
A Computational Approach to the Relationship between Radiation Induced Double Strand Breaks and Translocationsp. 251
Indexp. 261
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306449956
ISBN-10: 0306449951
Series: Basic Life Sciences
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 264
Published: 28th February 1995
Publisher: SPRINGER VERLAG GMBH
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 1.75
Weight (kg): 0.71

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