Complement in Health and Disease

By: Keith Whaley (Editor)

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Hardcover | Edition Number 2

At a Glance

Hardcover
396 Pages

Edition Type
Revised

Dimensions(cm)
16.4 x 24.4 x 2.7

Hardcover

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The complement system plays a major role in the host's defence against infections and in immune complex diseases. Although it is known to consist of a number of serum and membrane proteins that interact through a cascade, there is still a poor understanding of the exact nature of the components and their complex interaction. Many of the biological consequences of complement activation also await elucidation. This fully revised edition of Complement in Health and Disease provides an up-to-date account of how the system works and its effects on the host. Key topics covered include the history, phylogeny and evolution of the system; genetics and biochemistry; deficiency states and infection; immune complex diseases; complement and angioedema; anaphylatoxins; and diseases of the nervous system. The book is valuable both for those wanting an introduction to this complex area of immunology as well as those requiring a more detailed update on developments in specific topics.

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Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Immunology Other Branches of Medicine Pathology

List of Contributors
Preface
Introduction	p. 1
The phylogeny and evolution of the complement system	p. 39
Structure and organization of complement genes	p. 89
Synthesis of complement components in liver and at extra hepatic sites	p. 127
Genetic deficiencies of the complement system: an overview	p. 159
Human complement deficiency states and infection	p. 173
Complement, immune complexes and immune complex disease	p. 199
Hereditary angio-oedema	p. 229
Molecular genetics of C1-inhibitor and hereditary angio-oedema	p. 245
CR3 and its relationship with other phagocytic receptors	p. 269
Anaphylatoxins	p. 299
Cellular responses to the membrane attack complex	p. 325
Complement in diseases of the nervous system	p. 353
Index	p. 377
Table of Contents provided by Blackwell. All Rights Reserved.

Complement in Health and Disease

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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