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Comparative Genomics : Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families - David Sankoff

Comparative Genomics

Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families

By: David Sankoff (Editor), Joseph H. Nadeau (Editor)

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Published: 30th September 2000
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This study focuses on the evolving linear structure of the genome, from organelles and prokaryotes through to the multichromosomal nuclear genomes of plants and animals, based on modern genome map and sequence data. The collection brings together the diverse range of combinatorial optimization and probabilistic modeling techniques for analyzing genome rearrangements in the context of clinical cytogenetics, molecular genetics, population biology, microbial genomics, and the domesticated plant and animal genome projects. It critically compares functional and neutral conceptions of genome rearrangement and represents a concerted attack on the modeling and analytical problems associated with gene and genome duplication and with multigene families.

Preface. Foreword; W.F. Doolittle. Introduction. Comparative Genomics; D. Sankoff, J.H. Nadeau. 1. Mechanisms. Cytogenetics, Molecular Genetics, Population Genetics. 2. Organelles: Mitochondria and Chloroplast. Rearrangements in Small Genomes. 3. Combinatorial Algorithms. A New Set of Problems for a New Kind of Data. 4. Prokaryotes. Genome Scrambling versus Functional Clustering. 5. Statistics. The Quantification of Comparative Mapping. 6. Nuclear Genomes. Evolutionary Inference from Comparative Mapping. 7. Gene and Genome Duplication and Multi-gene Families. How Can Duplication by Analyzed?

ISBN: 9780792365846
ISBN-10: 0792365844
Series: Computational Biology
Audience: General
Format: Paperback
Language: English
Number Of Pages: 557
Published: 30th September 2000
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.98 x 16.26  x 2.95
Weight (kg): 0.89