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Combined Effects of Drugs and Toxic Agents : Modern Evaluation in Theorie and Practice :  Modern Evaluation in Theorie and Practice - Gerald Poch

Combined Effects of Drugs and Toxic Agents : Modern Evaluation in Theorie and Practice

Modern Evaluation in Theorie and Practice

Paperback

Published: September 2000
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Scientists struggling with the pharmaco-and toxicodynamic interactions of drugs and chemicals will find this a valuable reference to the relevant theoretical background of a complex field as well as a guide to practical, analytical procedures for the evaluation of experimental data. A mechanistically-based analysis of observed combination effects is backed up by numerous examples as well as computer-assisted plotting and curve fitting, using popular graphical software systems. Readers can proceed directly to the evaluation of their own dose-response experiments with respect to independent actions and additive interactions, where appropriate. The meanings of terms and acronyms are illucidated by a comprehensive glossary.

Principle considerations of drug actions and interactionsp. 1
Concepts and models of interactions - additivity and independencep. 15
Synergism potentiation and antagonism - phenomena and mechanismsp. 39
Evaluation by dose-response curvesp. 54
Evaluation by time-course studiesp. 67
Single-dose and other studiesp. 76
Combined-effect graph and other graphsp. 83
Applications of the new approach and observationsp. 89
A new and critical view of isobologramsp. 117
Comparison of the new with the conventional approachp. 122
Epilogp. 130
Appendix A - Glossary of terms and abbreviationsp. 132
Appendix B - Guide to practical work: exercise examplesp. 138
Referencesp. 151
Subject indexp. 162
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9783211824344
ISBN-10: 3211824340
Audience: General
Format: Paperback
Language: English
Number Of Pages: 167
Published: September 2000
Publisher: SPRINGER VERLAG GMBH
Country of Publication: AT
Dimensions (cm): 24.41 x 16.99  x 0.97
Weight (kg): 0.3