Combined Effects of Drugs and Toxic Agents : Modern Evaluation in Theorie and Practice

Modern Evaluation in Theorie and Practice

By: Gerald Pöch

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Paperback | 1 September 2000

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180 Pages

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24.38 x 16.76 x 0.97

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Scientists struggling with the pharmaco- and toxicodynamic interactions of drugs and chemicals will find this book a valuable reference to the relevant theoretical background of this complex field and an indispensible guide to practical, analytical procedures for evaluation of experimental data. A new, straightforward mechanistically based analysis of observed combination effects is backed up by numerous examples as well as by computer-assisted plotting and curve fitting - using popular graphical software systems. The reader thus can gain not only a modern understanding of this complex area but proceed directly to the evaluation of his own dose-response experiments with respect to independent actions, and additive interactions, where appropriate. The meanings of terms and acronyms in the literature, most of them used in this book also, are elucidated by a comprehensive glossary. This book represents a modern, theoretical and practical guide for all scientists dealing with this controversial and complex area of the action and interaction of drugs and chemicals.

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Principle considerations of drug actions and interactions	p. 1
Concepts and models of interactions - additivity and independence	p. 15
Synergism potentiation and antagonism - phenomena and mechanisms	p. 39
Evaluation by dose-response curves	p. 54
Evaluation by time-course studies	p. 67
Single-dose and other studies	p. 76
Combined-effect graph and other graphs	p. 83
Applications of the new approach and observations	p. 89
A new and critical view of isobolograms	p. 117
Comparison of the new with the conventional approach	p. 122
Epilog	p. 130
Appendix A - Glossary of terms and abbreviations	p. 132
Appendix B - Guide to practical work: exercise examples	p. 138
References	p. 151
Subject index	p. 162
Table of Contents provided by Blackwell. All Rights Reserved.

Combined Effects of Drugs and Toxic Agents : Modern Evaluation in Theorie and Practice

Modern Evaluation in Theorie and Practice

At a Glance

Paperback

Shipping

How to return your order

Defective items

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