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Clinical Handbook for Biotherapy : Jones and - Paula Trahan Rieger

Clinical Handbook for Biotherapy

Jones and

Paperback Published: 1st December 2007
ISBN: 9780763706494
Number Of Pages: 416

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This portable clinical handbook provides quick access to all major biological agents and their respective nursing management. Individual chapters on all major categories follow a consistent, clinically useful format of: overview of biology, mechanism of action, regulatory approvals, clinical tips, side effects, administration/dosing, and bibliography.

Prefacep. ix
Acknowledgmentsp. xi
Biotherapy: An Overviewp. 1
What Is Biotherapy?p. 3
How Is Biotherapy Different Than Chemotherapy?p. 3
What Is the Rationale for the Use of Biotherapy in Treating Cancer?p. 4
How Are Biological Agents Classified?p. 5
How Are Biological Agents Produced?p. 6
How Are Biological Agents Developed?p. 9
What Are the Major Biological Agents in Clinical Use?p. 11
Summaryp. 17
Referencesp. 18
Resourcesp. 20
The Immune Systemp. 21
What Is the Immune System?p. 21
Are There Different Types of Immunity?p. 21
What Are Antigens?p. 25
How Do Cells of the Immune System Communicate?p. 25
What Is the Major Histocompatibility Complex?p. 28
Which Tissues and Cells Are Part of the Immune System?p. 28
How Does the Specific Immune Response Work?p. 34
How Does the Immune System Protect Against Cancer?p. 38
Autoimmune Diseasesp. 42
Summaryp. 43
Referencesp. 45
The Interferonsp. 47
What Are the Interferons?p. 47
How Does Interferon Work?p. 48
How Is Interferon Made?p. 50
Which Diseases Are Treated with Interferon?p. 51
Clinical Experience: Interferon-[alpha]p. 51
Clinical Experience: Interferon-[beta]p. 58
Clinical Experience: Interferon-[gamma]p. 58
Regulatory Approvalsp. 59
What Are the Side Effects of Interferons?p. 60
Quick Summary: Roferon-Ap. 62
Quick Summary: Intron Ap. 66
Quick Summary: Infergenp. 73
Quick Summary: Alferon Np. 76
Quick Summary: Avonexp. 79
Quick Summary: Betaseronp. 83
Quick Summary: Actimmunep. 87
Clinical Pearlsp. 90
Referencesp. 92
The Interleukinsp. 95
What Are The Interleukins?p. 95
How Do The Interleukins Work?p. 98
What Is Interleukin-2?p. 99
Interleukin-1p. 106
Interleukin-4p. 111
Interleukin-6p. 113
Interleukin-10p. 115
Interleukin-12p. 119
Quick Summary: Proleukinp. 122
Clinical Pearlsp. 128
Referencesp. 132
Hematopoietic Growth Factorsp. 135
What Are the Hematopoietic Growth Factors?p. 135
How Are Hematopoietic Growth Factors Classified?p. 137
Which Cells Produce Hematopoietic Growth Factors?p. 141
How Do Hematopoietic Growth Factors Work?p. 142
Clinical Experience with Hematopoietic Growth Factorsp. 147
Regulatory Approvalsp. 151
What Are the Side Effects of HGFs?
Clinical Issuesp. 153
Investigational Agentsp. 153
Combinations of Hematopoietic Growth Factorsp. 157
Future Directionsp. 158
Quick Summary: Neumegap. 159
Quick Summary: Neupogenp. 164
Quick Summary: ProCritp. 170
Quick Summary: Epogenp. 177
Quick Summary: Leukinep. 181
Clinical Pearlsp. 192
Referencesp. 194
Monoclonal Antibodiesp. 197
What Are Monoclonal Antibodies?p. 197
How Do Monoclonal Antobodies Work?p. 197
How Are Monoclonal Antibodies Made?p. 199
Clinical Studiesp. 202
Regulatory Approvalp. 208
What Are the Side Effects of MAB Therapy?p. 208
What Are Obstacles to Treatment with MABs?p. 212
Are MABs Used in Other Diseases Besides Cancer?p. 214
Quick Summary: Rituxanp. 216
Quick Summary: Herceptionp. 221
Quick Summary: Zenapaxp. 227
Quick Summary: Orthoclone OKT3p. 230
Clinical Pearlsp. 235
Referencesp. 237
Immunomodulators, Differentiation Agents, and Vaccinesp. 239
Bacillus of Calmette and Guerinp. 239
What Is BCG?p. 239
How Does BCG Work?p. 239
Regulatory Approvalp. 240
What Side Effects Are Seen with BCG?p. 241
Quick Summary: TheraCysp. 242
Retinoidsp. 247
What Are the Retinoids?p. 247
How Do the Retinoids Work?p. 247
Which Diseases Are Treated with the Retinoids?p. 248
Regulatory Approvalsp. 249
What Side Effects Are Seen with the Retinoids?p. 249
Quick Summary: Vesanoidp. 251
Tumor Vaccines: Active Specific Immunotherapyp. 255
What Types of Vaccines Are Used?p. 256
What Strategies Are Used to Increase Immunogenicity?p. 257
How Are Vaccines Used Clinically?p. 259
How Are Vaccines Administered?p. 259
What Side Effects Are Seen with Vaccines?p. 259
How Should Patients Be Managed?p. 260
Referencesp. 261
Patient Managementp. 263
How Should Patients Be Assessed?p. 263
What Are Important Considerations for Administration of Biotherapy?p. 268
How Should Side Effects Be Managed?p. 272
Radiation Precautionsp. 287
Sexualityp. 288
Ambulatory Carep. 288
What Are Important Considerations in Patient Education?p. 289
Are Reimbursement Issues Important?p. 293
Summaryp. 297
Referencesp. 298
Resourcesp. 300
Diseases Treated with Biotherapyp. 301
AIDS-Related Kaposi's Sarcomap. 301
Chronic Myelogenous Leukemiap. 306
Hairy Cell Leukemiap. 316
Malignant Melanomap. 321
Multiple Sclerosisp. 331
Non-Hodgkin's Lymphomap. 338
Renal Cell Carcinomap. 345
Viral Hepatitisp. 352
Plans of Care for Patients Receiving Biological Agentsp. 361
The University of Texas M. D. Anderson Cancer Center Biotherapy Patient Teaching Planp. 373
Normograms for Determination of Body Surface Area from Height and Weight (Adults)p. 381
Glossaryp. 383
Indexp. 391
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780763706494
ISBN-10: 0763706493
Series: Jones and
Audience: Tertiary; University or College
Format: Paperback
Language: English
Number Of Pages: 416
Published: 1st December 2007
Country of Publication: US
Dimensions (cm): 20.32 x 12.7  x 2.16
Weight (kg): 0.41