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Classical Genetic Research and its Legacy : The Mapping Cultures of Twentieth-Century Genetics - Hans-Jorg Rheinberger

Classical Genetic Research and its Legacy

The Mapping Cultures of Twentieth-Century Genetics

Hardcover Published: 7th October 2004
ISBN: 9780415328494
Number Of Pages: 256

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With the rise of genomics, the life sciences have entered a new era. This book provides a comprehensive history of mapping procedures as they were developed in classical genetics. An accompanying volume - From Molecular Genetics to Genomics - covers the history of molecular genetics and genomics.

The book shows that the technology of genetic mapping is by no means a recent acquisition of molecular genetics or even genetic engineering. It demonstrates that the development of mapping technologies has accompanied the rise of modern genetics from its very beginnings. In Section One, Mendelian genetics is set in perspective from the viewpoint of the detection and description of linkage phenomena. Section Two addresses the role of mapping for the experimental working practice of classical geneticists, their social interactions and for the laboratory 'life worlds'.

With detailed analyses of the scientific practices of mapping and its illustration of the diversity of mapping practices this book is a significant contibution to the history of genetics. A companion volume from the same editors - From Molecular Genetics to Genomics: The Mapping Cultures of Twentieth Century Genetics - covers the history of molecular genetics and genomics.

List of figuresp. xiii
Notes on contributorsp. xvii
Acknowledgmentsp. xix
Introductionp. 1
Mendelian genetics and linkage mappingp. 7
Linkage before Mendelism? Plant-breeding research in Central Europe, c.1880-1910p. 9
Nineteenth-century breeders' work on correlationp. 9
Early Mendelian views of correlationp. 13
Conclusionp. 15
Carl Correns and the early history of genetic linkagep. 21
Introductionp. 21
Experiments with Matthiolap. 22
Correns' chromosome theoryp. 25
Concluding epistemological considerationsp. 29
Applying and extending the notion of genetic linkage: the first fifty yearsp. 34
Compound unit-charactersp. 35
Chromosomes constrain independent segregationp. 36
Linkage as an analytic toolp. 38
Recombination mechanics: chiasmatype or else?p. 41
Linkage mapsp. 45
The cytological linkp. 49
Conclusions: the impact of the linkage concept on genetic analysisp. 52
Classical genetics and the geography of genesp. 57
Introductionp. 57
Historiography of genetic mappingp. 58
Hybrids all the way down (and up): problems, protocols, and mapsp. 60
Pragmatic aspects of geographical mapsp. 73
Conclusionp. 84
Mapping work, mapping collectives, mapping culturesp. 89
Mapping and seeing: Barbara McClintock and the linking of genetics and cytology in maize genetics, 1928-35p. 91
Emerson, maize, and geneticsp. 92
Cytology meets corn geneticsp. 101
Conclusion: seeing and mappingp. 109
The ABO blood groups: mapping the history and geography of genes in Homo sapiensp. 119
Introductionp. 119
The human genome diversity project: contesting disciplinary boundaries and the historical legacy of ABO blood group researchp. 121
Mapping the history and geography of genes in Homo sapiensp. 124
Conclusion: mapping people, mapping fliesp. 165
Mapping as technology: genes, mutant mice, and biomedical research (1910-65)p. 173
Introductionp. 173
Inbreeding, and physiological studies within the Bussey schoolp. 174
Mouse genetics as tool: the Jackson Biomedical Culturep. 185
Scaling-up: mapping in the era of big biomedecinep. 193
Conclusionp. 200
Commentariesp. 205
Genetic mapping: approaches to the spatial topography of geneticsp. 207
Maps as representationsp. 208
Maps as discursive devices for making connections and assemblagesp. 209
Maps as devices to materialize questionsp. 210
Maps as tools for control, appropriation, and ideological expressionp. 210
Mapping as a fundamental cognitive processp. 211
Mapping and knowledge spacesp. 212
Mapping as boundary objects-devices for handling multiplicity, heterogeneity, and messinessp. 212
Maps as spatial and temporal narrativesp. 213
Unmapping and remappingp. 214
Evolution, mapping, narrativity, and reflexive difficultiesp. 215
Mapping as a cultural practicep. 220
The diversity of mapsp. 221
Mapping as a cultural categoryp. 222
The stabilization of cartographic knowledgep. 223
Concluding remarksp. 225
Indexp. 229
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780415328494
ISBN-10: 0415328497
Series: Routledge Studies in the History of Science, Technology, and
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 256
Published: 7th October 2004
Country of Publication: GB
Dimensions (cm): 23.93 x 16.15  x 1.93
Weight (kg): 0.52
Edition Number: 1