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Cilia, Mucus, and Mucociliary Interactions - Nadav Liron

Cilia, Mucus, and Mucociliary Interactions

By: Nadav Liron (Editor), Ervin Ostfeld (Editor), Zvi Priel (Editor), Yehudah Roth (Editor)

Hardcover Published: 1st February 1998
ISBN: 9780824701383
Number Of Pages: 616

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Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions.
Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucociliary Interactions
discusses the genetic determinants of mucociliary system structure and function
explains ciliary wave activity in cell-cell communication
elucidates many of the key physiological processes in ciliary regulation
reveals possible means of treating irregularities in mucus secretion and clearance
improves understanding of clinical syndromes, including abnormalities pertaining to nasal sinuses, upper and lower airways, and the systemic role of cilia
approaches the clinical management of mucociliary dysfunction logically using currently available diagnostic and therapeutic techniques
and much more
Containing bibliographic citations, tables, equations, drawings, and photographs, this exhaustive guide is essential reading for physiologists, pulmonologists, otolaryngologists, pediatricians, microbiologists, basic scientists, and graduate and medical school students in these disciplines.

Prefacep. iii
About the Editorsp. v
Contributorsp. xv
In Memory of Professor Alex Silberberg 1923-1993p. xxvii
Basic Science
Dynein Regulation
Molecular Biology of Axonemal Dynein and Its Role in Ciliary Motilityp. 1
Modeling Outer Dynein Arm Activity and Its Relation to the Ciliary Beat Cyclep. 13
Ciliary Regulation
Regulation of Outer Arm Dynein Activity via Light Chain Phosphorylationp. 21
Inhibitory and Excitatory Neural Regulation of the Mucociliary Transport Systemp. 27
The Nucleoside Diphosphate Kinase and Chloride-Sensitive GTP-Dependent Phosphorylation in Apical Membrane from Ciliated Airway Cellsp. 39
Regulation of Ciliogenesis and Ciliated Cell Specific Genesp. 43
Mucus Transporting Cilia: A Model System for Investigating Calcium Signaling in Electrically Inexcitable Cellsp. 49
Intercellular Communication in Mammalian Airway-Ciliated Epitheliap. 59
[beta subscript 2] Agonist Terbutaline Makes the Ciliary Beat Frequency of Freshly Isolated Human Airway Cells Refractory to Calcium Signalingp. 71
Ionic Mechanisms in Olfactory Reception: Perspective Through Ion Channels in the Vertebrate Olfactory Ciliap. 79
Modeling of Ciliary Function
Coupling the Internal Axoneme Mechanics of Cilia and Flagella with External Fluid Dynamicsp. 87
Metachronal Coordination as the Result of Hydrodynamical Couplingp. 97
Metachronal Wave, Ciliary Stroke, and Mucus Propulsionp. 103
Roles of Cilia in Filter Feeding and Mucus Transportp. 119
Basic Aspect of Mucus
Digital Microrheometryp. 127
Regulation of Differentiation and Mucin Secretion in Tracheobronchial Epithelial Cell Culturesp. 137
Intracellular Regulation of Mucin Secretion in Airway Epithelial Cells In Vitrop. 143
Cellular Basis for the Purinergic Regulation of Mucin Secretion in the Airwaysp. 153
Polymer Biophysics of Mucus in Cystic Fibrosisp. 167
Evolution of the Frog Palate Model for Mucociliary Clearance--1970-1997p. 191
Airway Mucociliary Epithelium Injury and Repairp. 203
Clinical Practice
Mucociliary Clearance in Various Septal Deformities
Septal Deformities Can Influence the Mucociliary Transport Impairment of the Middle Turbinate Mucosap. 219
Aspects of Mucociliary Flow and Mechanics in Nasal Cavity and Sinusesp. 227
Clinical Studies in Human Tubal Structures
Clearance Function of the Eustacian Tube: What We Know, What We Don't Knowp. 231
Clinical Significance of Tubotympanal Mucociliary Clearance in Otitis Media with Effusionp. 249
Mucociliary Function of Respiratory Epithelium--Human and Animal Studies
Effects of Urban Air Pollution on Mucociliary Clearancep. 253
Bridging the Gap Between Airway Ion Transport and Mucociliary Clearance
Improved Mucociliary Clearance Following Nebulization with Hypertonic Saline in Adults with Cystic Fibrosisp. 265
Ciliary Transport of Sputum Is Governed by Its Osmolalityp. 281
Mucociliary Clearance in the Guinea Pig is Increased by Ouabain (i. v.) and by Hypertonic Saline (14.4%) Aerosolp. 285
Interventions that Increase Mucociliary Clearance in Asthmatic and Healthy Subjectsp. 295
Mucociliary and Cough Clearance: Role of Ion Transport and the P[subscript 2]Y[subscript 2] Receptor-Mediated Systemp. 307
Laboratory and Clinical Studies of Mucus
Surface Properties of Respiratory Secretions: Relationship to Mucus Transportp. 317
Cellular Components of Airway Secretions: Recruitment and Regulationp. 325
DNA and Actin Filament Ultrastructure in Cystic Fibrosis Sputump. 333
Airway Bacteria and Mucus Production
Is Bacterial Colonization of the Airways Relevant?p. 343
Mucin Synthesis Is Upregulated at the Transcriptional Level by P. aeruginosa LPSp. 349
Tissue Distribution of Secretory Mucins and Alterations of Mucin Gene Expression in Chronic H. pylori Infection of the Stomachp. 353
Effect of Pseudomonas aeruginosa Alginate on Airway Mucus Secretionp. 367
Medical Modulation of Mucus
Analysis of Mucociliary Dysfunctionp. 373
Effects of Mucokinetic Agents on Nasal Mucusp. 379
Pharmacologic Management of Mucus Retention Based on a Taxonomy of Mucoactive Medicationsp. 383
Experimental Models for Mucus Drug Researchp. 391
Definition and Diagnosis of Primary and Secondary Mucociliary Disfunction
Ciliary Beat Frequency, Ultrastructural Abnormalities, and Mucus Clearance in Primary Ciliary Dyskinesia (PCD)p. 399
Diagnosis of Primary Ciliary Dyskinesiap. 407
Mucociliary Clearance in Health and Disease: Qualitative and Quantitative Analysisp. 429
Human Ciliated Epithelium In Vitro--Mechanisms of Injury and Protectionp. 461
Biochemical and Pharmacological Regulation of Mucociliary Activity
Regulation of Mucociliary Activity in the Upper Airways by Nitric Oxide--Clinical Implicationsp. 473
Ciliary Stimulation by Extracellular ATP in Frog Esophagus and Palate Epitheliump. 491
The Messianic Relationship Between Inspiration and Expectorationp. 501
Mucociliary Clearance in Paranasal Sinuses
An Approach to Imaging Interpretation in Paranasal Sinus Diseasep. 509
Miscellaneous Ciliary Function
Chronic Sinusitis in Relation to the Lower Airwayp. 515
Immune Responses in the Chronic Inflammatory Process Within the Paranasal Sinus Mucosap. 525
Character of Bronchopulmonary Changes in Patients with Primary Ciliary Dyskinesiap. 543
Diagnosis, Treatment, and Prevention of Mucociliary Dysfunction
Genetic Counseling of Adults with Primary Ciliary Dyskinesia or Cystic Fibrosisp. 551
Clinical Molecular Biology
Preliminary Exclusion of Chromosome 7 as a Potential Location of a Gene for Primary Ciliary Dyskinesiap. 557
Bend Shapes and Molecular Mechanisms of Flagellap. 563
Indexp. 569
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780824701383
ISBN-10: 0824701380
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 616
Published: 1st February 1998
Publisher: CRC PR INC
Country of Publication: US
Dimensions (cm): 23.39 x 15.6  x 3.33
Weight (kg): 1.04
Edition Number: 1