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Chromogranins : Functional and Clinical Aspects - Karen B. Helle


Functional and Clinical Aspects

By: Karen B. Helle (Editor), Dominique Aunis (Editor)

Hardcover Published: 31st December 2000
ISBN: 9780306464461
Number Of Pages: 405

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Proceedings of Session VII of the Tenth International Symposium on Chromaffin Cell Biology, held August 25-28, 1999, in Bergen, Norway, and a post-symposium workshop on Chromogranins: from Fundamental Physiology to Clinical Aspects, held August 28, 1999, on board the coastal steamer MS Richard With.
This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically active sequences and the clinical perspectives of the circulation prohormones.

Industry Reviews

`I recommend Chromogranins for students and basic scientists interested not only in chromogranins but also in peptide processing and secretory granule proteins.'
Trends in Endocrinology and Metabolism, 13:6 (2002)

The Chromogranins: Historical Perspectivesp. 3
Chromogranins: Current Concepts: Structural and Functional Aspectsp. 21
Intracellular Functions
Signal-Mediated Sorting of Chromogranins to Secretory Granulesp. 41
The Condensed Matrix of Mature Chromaffin Granules: The Soluble Form of Dopamine [beta]-hydroxyase is Catalytically Inactivep. 55
Functional Role of Chromogranins: The Intragranular Matrix in the Last Phase of Exocytosisp. 69
Inositol 1,4,5-Trisphosphate Receptor and Chromogranins A and B in Secretory Granules: Co-localization and Functional Couplingp. 83
Transciption, Expression, and Secretion
Regulation of Chromogranin A Transcription and Catecholamine Secretion by the Neuropeptide PACAP Stimulation and Desensitizationp. 97
Neuroendocrine Cell-Specific Expression and Regulation of the Human Secretogranin II Genep. 113
Characterization of Chromogranins in the Frog Rana ridibunda. Structure, Expression, and Functional Implicationsp. 125
Expression of Equine Chromogranin A cDNA Sequence and Distribution of mRNA in Endocrine and Exocrine Tissuesp. 137
Salivary Secretion of Chromogranin A Control by Autonomic Nervous Systemp. 143
Tissue-Specific Processing, Transport and Distribution
Proteolytic Processing of Chromograninsp. 155
Endothelial handling of chromogranin Ap. 167
Tissue Plasminogen Activator and Chromaffin Cell Functionp. 179
Chromogranin A Immunoreactivity in Neuroendocrine Cells in the Human Gastrointestinal Tract and Pancreasp. 193
Chromogranin A and Its Derived Peptides in the Rat and Porcine Gastro-Entero-Pancreatic System: Expression, Localization, and Characterizationp. 205
Functional Aspects of Biologically Active Sequences
Regulation of Parathyroid Secretion: Chromogranins, Chemokines and Calciump. 217
Vasostatins: Vascular Targetsp. 225
Vasostatins: Dilators of Bovine Resistance Arteriesp. 239
Pancreastatin: Biological Effects and Mechanisms of Actionp. 247
The Novel Catecholamine Release-Inhibitory Peptide Catestatin (Chromogranin A[subscript 344-364]): Properties and Functionp. 263
Secretoneurin--A Novel Link Between the Nervous and the Immune System: Conservation of the Sequence and Functional Aspectsp. 279
Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial Cellsp. 291
Antibacterial and Antifungal Peptides Derived from Chromogranins and Proenkephalin-A: From Structural to Biological Aspectsp. 299
Clinical Aspects of the Circulating Prohormones
Measurements of Chromogranins and Chromogranin-related Peptides by Immunological Methodsp. 319
Chromogranins as Diagnostic and Prognostic Markers in Neuroendocrine Tumoursp. 329
Assessment of Chromogranin A Using Two-site Immunoassay: Selection of a Monoclonal Antibody Pair Unaffected by Human Chromogranin A Processingp. 339
Chromogranin A and Tumor Necrosis Factor-[alpha] (TNF) in Chronic Heart Failurep. 351
Chromogranin A (CGA) and the Enterochromaffin-like (ECL) Cellp. 361
Chromogranins in Non-endocrine Tumoursp. 369
Concluding Remarks
Chromogranin A in Human Diseasep. 377
A Physiological Role for the Granins as Prohormones for Homeostatically Important Regulatory Peptides? A working hypothesis for future researchp. 389
Author Indexp. 399
Subject Indexp. 401
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780306464461
ISBN-10: 0306464462
Series: Advances in Experimental Medicine and Biology
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 405
Published: 31st December 2000
Country of Publication: US
Dimensions (cm): 25.4 x 17.78  x 2.39
Weight (kg): 0.97

Earn 678 Qantas Points
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