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Chiral Separations by Chromatography : American Chemical Society Publication - Satinder Ahuja

Chiral Separations by Chromatography

American Chemical Society Publication

Hardcover Published: 1st April 2000
ISBN: 9780841236318
Number Of Pages: 240

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The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.

" very timely ... This is a highly recommended volume for those wishing to learn about chiral chromatography from a practical viewpoint ... the book should be in every library" Process Research and Development Journal

An Overviewp. 3
Chirality and Biological Activityp. 3
Chiral Separationsp. 6
Chiral Stationary Phasesp. 8
Modern CSP Designp. 9
Preparative Separationsp. 10
Regulatory Perspectivesp. 11
Perspectives on Evaluation of Stereoisomers as Drug Candidatesp. 14
Marketing Status of Single Isomersp. 16
Development of Single Enantiomersp. 16
Pharmacokineticsp. 23
Detoxificationp. 26
Stabilityp. 29
Industrial Perspectivesp. 30
Regulatory Guidelinesp. 33
Review of Stereochemistryp. 38
Brief Historyp. 39
Stereoisomerismp. 40
Classificationp. 45
Nomenclaturep. 46
Resolutionp. 48
Enantiopurityp. 49
Determination of Absolute Configurationp. 52
Separation Methodsp. 58
Thin-Layer Chromatographyp. 59
Gas Chromatographyp. 63
High Pressure Liquid Chromatographyp. 74
Supercritical Fluid Chromatographyp. 76
Capillary Electrophoresisp. 77
Detection Methodsp. 81
Detectors for TLCp. 81
Detectors for GCp. 82
Detectors for HPLCp. 83
Specific Detectors for Chiral Compoundsp. 85
Desirable Features of Chiral Stationary Phasesp. 92
Desirable Featuresp. 92
Types of CSPsp. 96
Comparison of Various CSPsp. 108
Understanding Chiral Chromatographyp. 111
Enantioselective Interactionsp. 111
Chromatographic Enantioselectivityp. 114
Inclusionp. 120
Transition Metal Complexesp. 122
Separations on Protein Columnsp. 122
Molecular Modelingp. 125
Method Developmentp. 128
Stereoisomeric Interactionsp. 128
Chromatographic Methodsp. 130
Modes of Separation in HPLCp. 131
Chromatography of Diastereomeric Derivativesp. 132
Enantiomeric Resolution using Chiral Mobile-Phase Additivesp. 132
Enantiomeric Resolution using Chiral Stationary Phasesp. 135
Computerized Methodsp. 140
Preparative Separationsp. 145
Displacement Chromatographyp. 146
Elution Chromatographyp. 147
Method Selection and Selected Applicationsp. 168
Where to Start?p. 168
Study the Moleculep. 169
Which Method to Use?p. 170
High Pressure Liquid Chromatographyp. 170
Gas Chromatographyp. 208
Supercritical Fluid Chromatography (SFC)p. 212
Capillary Electrophoresis (CE)p. 214
Comparative Separationsp. 216
Appendixp. 221
Indexp. 229
Table of Contents provided by Syndetics. All Rights Reserved.

ISBN: 9780841236318
ISBN-10: 0841236313
Series: American Chemical Society Publication
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 240
Published: 1st April 2000
Publisher: American Chemical Society
Country of Publication: US
Dimensions (cm): 24.3 x 16.2  x 1.7
Weight (kg): 0.5