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Chemokines : Volume 287 - John N. Abelson


Volume 287

By: John N. Abelson (Editor), Melvin I. Simon (Editor), Richard Horuk (Editor)

Hardcover Published: 26th September 1997
ISBN: 9780121821883
Number Of Pages: 421

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Chemokines are major mediators of immune cells and are involved in a wide range of proinflammatory human diseases, including rheumatoid arthritis, multiple sclerosis, and organ transplant rejection. It has recently been discovered that their receptors are involved in HIV infection. The characterization of these molecules and their receptors is thus of primary importance in understanding a number of human diseases and infections. This volume and its companion Volume 288 on Chemokine Receptors provide comprehensive experimental protocols used in this field of research.
Key Features
* C-X-C Chemokines
* C-C and C Chemokines
* Other Methods

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C-X-C Chemokines
Expression, Purification, and Characterization of Escherichia coli Derived Recombinant Human Melanoma Growth Stimulating Activity
Purification and Identification of Human and Mouse Granulocyte Chemotactic Protein-2 Isoforms
Synthesis of Chemokines by Native Chemical Ligation
Molecular Approaches to Structure-Function Analysis of Interleukin-8
Alanine Scan Mutagenesis of Chemokines
Biological Assays for C-X-C Chemokines
Characterization of Quaternary Structure of Interleukin-8 and Functional Implications
C-C and C Chemokines
Isolation of Human Monocyte Chemotactic Proteins and Study of their Producer and Responder Cells by Immunotests and Bioassays
Assays for Macrophage Inflammatory Proteins
Gene Expression of Rantes
Expression of Chemokine Rantes and Production of Monoclonal Antibodies
Biological Responses to C-C Chemokines
Gene Targeting Strategies to Study Chemokine Function in Vivo
Lymphotactin: A New Class of Chemokine
Isolation and Purification of Neutrophil Activating Peptide 4: A Chemokine Missing Two Cysteines
Other Methods
Chemical Synthesis Purification and Folding of C-X-C and C-C Chemokines
Identification of Inflammatory Mediators by Screening for Glucocorticoid-Attenuated Response Genes
Chemokine-Induced Human Lymphocyte Infiltration and Engraftment in huPBL-SCID Mice
HighThroughput Screening for Identification of Rantes Chemokine Expression Inhibitors
Transgenic Methods to Study Chemokine Function in Lung and Central Nervous System
Chemokines and Chemokine Receptors in Model Neurological Pathologies: Molecular and Immunocytochemical Approaches
Synthesis and Evaluation of Fluorescent Chemokines Labeled at the Amino Terminal
Solid-Phase Binding Assay to Study Interaction of Chemokines with Glycosaminoglycans
Biological Activity of C-X-C and C-C Chemokines in Leukocyte Subpopulations in Human Whole Blood
Author Index
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9780121821883
ISBN-10: 0121821889
Series: Methods in Enzymology : Book 287
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 421
Published: 26th September 1997
Country of Publication: US
Dimensions (cm): 22.91 x 15.19  x 2.54
Weight (kg): 0.78