Chemistry and Properties of Biomolecular Systems Vol. II : Proceedings of the Second Joint Greek-Italian Meeting on Chemistry and Biological Systems and Molecular Chemical Engineering, Cetraro, Italy, October 1992

By: Guido Barone (Editor), Nino Russo (Editor), Jane Anastassopoulou (Editor)

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During the last decade, interest in the chemistry of biological systems, as well as in molecular chemical engineering, has grown considerably. Many fields in modern chemistry are contributing to a better understanding of elementary mechanisms of various biological processes and this has resulted in the development of new classes of organic and organometallic compounds with specific and high biological activity. Such a multidisciplinary approach creates opportunities for an exchange of ideas and the need to create a common language. This volume contains a collection of papers, written by leading scientists which collectively provide a rich overview of current research activities relating to the chemistry of biological systems. These papers emphasize the interdisciplinary nature of this research. For researchers in academia and industry whose work involves the chemistry and properties of biomolecular systems.

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Preface
Intrinsic and Environmental Effects on Protomeric Equilibria in the Ground and Excited Electronic States of Biological Systems	p. 1
Ternary Complexes of Pt(II) and Pt(IV) with Aminoacids and Nucleobases	p. 19
Free Radicals in Biological Systems	p. 23
The Role of Oxygen in Radiolysis of Aqueous Solutions of Magnesium-Guanosine-5'-Monophosphate Complexes	p. 31
Interaction of Alkaline and Alkaline-Earth Metal Ions with Nucleosides	p. 37
Thermal Behaviour of Three Ribonucleases	p. 49
Denaturation of Biological Macromolecules: New Programs for the Deconvolution of DSC Measurements	p. 67
Solvent Effects on the Molecular Organization and Properties of Biological Systems	p. 79
Superstructural Informations in the Base Sequences of Nucleic Acids	p. 93
DNA Superstructures: Relevance on Physicochemical Properties and in Recognition Mechanism with Proteins	p. 109
Redox and PH-Sensitive Polymer-Grafted Membranes: Thermodynamic Characteristics in Drug Delivery	p. 127
Iron-Sulfur Proteins: Part II Valence-Specific Assignment in Oxidized HIPIP Through [superscript 1]H NMR Spectroscopy	p. 143
Chlorophyll A Molecular Organization and Photoreactivity	p. 159
Biocompatible Catalysis of Polyene Polymers by Manganese [superscript (III)] Porphyrins	p. 175
Engineering of Bovine Seminal Ribonuclease: Expression of the Secreted Recombinant Protein	p. 187
Membrane Operation in Biochemical Processing	p. 193
The Conformational Properties of (-)-Dolastatin 10, a Powerful Antineoplastic Agent	p. 205
In Vitro Solubilization of a Recombinant Elongation Factor TU, Carrying the ASP 138 ASN Mutation	p. 211
Search for Preparing Antibiotics Active Against Resistant Strains of Bacteria and Wider Spectrum of Activity	p. 219
The Mutagenic Heterocyclic Amines in Cooked Foods	p. 233
On the Possible Structure-Activity Relationships in the Food Mutagen Imidazoquinoxaline (IQX) Series	p. 243
Elongation Factor TU, a Model Protein for Studying Structural-Functional Relationships and Regulatory Mechanisms	p. 249
Hybrid Antibiotics: Aminoglycoside 3-Quinolone or [beta]-Lactam Amides	p. 267
Complexes of Dirhodium Trifluoroacetate with Nucleosides and Nucleotides	p. 271
Synthesis of Amino Acid and Peptide Derivatives of Aminoglycosides Targeted Against Resistance of Bacteria	p. 277
Fusion and Aggregation of Phospholipid Vesicles: Experimental Problem of the Distinction	p. 281
A Molecular Dynamics Study of TYR-DALA-PHE-GLY-NH[subscript 2] and of Its 18-Crown-6-Ether Complex. A Model [mu]-Opioid Peptide and Its Interaction with a Simulated Receptor Site	p. 291
Subunit Assembly in Bovine Seminal Ribonuclease	p. 301
Conformational Studies in Solution on Cyclolinopeptide A Analogs. A Two-D NMR Study of Cyclo [actual symbol not reproducible]	p. 313
Homogeneous Catalytic Hydrogen Formation Using Dinuclear Multiply Bonded Complexes of Molybdenum (III) and Tungsten (III) and Low-Valency Metal Ions, M=Cr(II), V(II), in Aqueous Acidic Solutions	p. 321
A Theoretical Study on the Protonation of Nucleic Acid Pyrimidine and Purine Bases	p. 331
Phosphorylation of an Overexpressed Yeast RAS2 Protein During the G1 Phase of the Cell Cycle	p. 353
Effect of Isomerism at Non-Leaving Ligands in Platinum Anticancer Drugs	p. 363
A Photochemical Approach to Study the Antimitotic-Drugs Tubulin Interaction	p. 369
A QSAR Model of the Isoelectric Points and of the Atomic Charges of Amino Acids	p. 381
On the Molecular and Supramolecular Structure of Elastin	p. 389
Conformational Analysis of Dolavaline, Dolaisoleuine, Dolaproine and Dolaphenine Unusual Amino Acids	p. 405
Index	p. 415
Table of Contents provided by Blackwell. All Rights Reserved.

Chemistry and Properties of Biomolecular Systems Vol. II : Proceedings of the Second Joint Greek-Italian Meeting on Chemistry and Biological Systems and Molecular Chemical Engineering, Cetraro, Italy, October 1992

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