| Preface | |
| Gowland Hopkins Lecture: Making Methionine: A Love Affair with Folate | p. 1 |
| Structure Elucidations of Dimeric Pteridines | p. 9 |
| A Selective Procedure for 6-Substituted Pterin Derivatives: Synthesis and Substitution of Pterin 6-Triflate | p. 19 |
| Solution and Solid Phase Synthesis of Pteridines, Purines and Related Compounds | p. 25 |
| Synthesis of Pteridines with C-2 and C-6 Functional Group Diversity | p. 31 |
| Stereospecific Synthesis of 2-Desamino-Tetrahydropterins as Probes of Hydroxylase Cofactor Recognition | p. 37 |
| New Pyranopterin Chemistry Related to Molybdenum and Tungsten Enzymes | p. 43 |
| Application of FDCD Spectroscopy for Determination of Chiralities of Biologically Important Pteridines | p. 49 |
| Photo-Oxidation of Sepiapterin Produces Pterin-6-Carboxylic Acid and H[subscript 2]O[subscript 2] In Vitro | p. 55 |
| Regulation of Tyrosine Hydroxylase by S-Glutathiolation: Relevance to Conditions Associated with Dopamine Neuronal Damage | p. 61 |
| The Conformation of Tetrahydro-Biopterin Free and Bound to Aromatic Amino Acid Hydroxylases and NOS | p. 67 |
| Regulatory Properties of the Tetrahydropterin Cofactor in the Reaction Catalyzed by Human Tyrosine Hydroxylase Isoforms 1-4 | p. 73 |
| Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes | p. 79 |
| Interaction of Phosphorylated Tyrosine Hydroxylase with 14-3-3 Proteins: Effects on Phosphorylation Kinetics | p. 85 |
| Mechanistic Studies of Tryptophan Hydroxylase | p. 91 |
| Role of Phe313/Trp326 in Determining Substrate Specificity in Tryptophan and Phenylalanine Hydroxylases | p. 97 |
| Possible Contributions of Labile Asparagine Residues to Differences in Regulatory Properties of Human and Rat Phenylalanine Hydroxylase | p. 103 |
| 3-(2-Thienyl)-L-Alanine as a Competitive Substrate Analogue and Activator of Human Phenylalanine Hydroxylase | p. 109 |
| The N-Terminus of Human Tyrosine Hydroxylase is Responsible for its Association with Phospholipid Bilayers | p. 115 |
| Mechanisms of Tyrosine Hydroxylase Activation by Stress Activated Protein Kinases | p. 121 |
| Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase | p. 127 |
| Mutation of W457 Alters N-Hydroxy-L-Arginine Oxidation by Inducible NO Synthase: A Single Turnover Study | p. 133 |
| Regulation of Rat Hepatic Phenylalanine Hydroxylating System In Vivo | p. 139 |
| Estradiol Modulates GTP Cyclohydrolase I Gene Expression in Brain Catecholaminergic Systems | p. 145 |
| PKC-Mediated Regulation of GTP Cyclohydrolase I in Mast Cells and Renal Mesangial Cells | p. 151 |
| Regulation of GTP Cyclohydrolase I by Estrogen | p. 157 |
| Sexually Dimorphic GTP Cyclohydrolase I Gene Expression is Independent of Sex Hormones | p. 163 |
| Studies on the Reaction Mechanism of GTP Cyclohydrolase I | p. 169 |
| Site-Directed Mutagenesis of Residues in the Active Site of Sepiapterin Reductase | p. 175 |
| Determination of Residues Of Sepiapterin Reductase Phosphorylated by Ca[superscript 2+]/Calmodulin-Dependent Protein Kinase II | p. 181 |
| The Interaction of GTP Cyclohydrolase I and GTP Cyclohydrolase Feedback Regulatory Protein Can be Detected Using the Yeast Two-Hybrid System | p. 187 |
| Co-Induction of Tetrahydrobiopterin and Catecholamine Syntheses in V-1-Overexpressing PC12D Cells | p. 193 |
| Sepiapterin Administration Raises Tissue BH[subscript 4] Levels More Efficiently than BH[subscript 4] Supplement in Normal Mice | p. 199 |
| Cells Take up BH[subscript 4], Oxidize it, and the Oxidized Biopterin is Preferentially Released | p. 205 |
| Catecholamines-Up, a Negative Regulator of Tyrosine Hydroxylase and GTP Cyclohydrolase I in Drosophila Melanogaster | p. 211 |
| The Pteridine Pathway in the Zebrafish, Danio Rerio: Development in Neural Crest-Derived Cells and its Control by GTP Cyclohydrolase I | p. 217 |
| Pteridine and Nitric Oxide Biosynthesis in Physarum Polycephalum | p. 223 |
| Pteridines and Pigment Granules of Wing Scales Concerned with Sexual Difference in Wing's Capability Reflecting Near-UV Rays in the Japanese Cabbage Butterfly, Pieris Rapae Crucibora | p. 229 |
| Tetrahydrobiopterin, Nitric Oxide Synthesis and cGMP Concentrations in Mutants of Physarum Polycephalum with Altered Sporulation Behavior | p. 235 |
| BH[subscript 4] and NOS are Involved in Light Controlled Development of Sporangiophores in the Fungus Phycomyces Blakesleeanus | p. 241 |
| Determination of Tetrahydropterins as Native Pteridines in Two Microorganisms, Tetrahymena Pyriformis and E. coli | p. 247 |
| Identification of the Sulfurtransfer Pathway for the Generation of the Dithiolene Moiety of Molybdopterin in Escherichia Coli | p. 253 |
| Tetrahydrobiopterin and Vascular Endothelial Function | p. 259 |
| L-Ascorbic Acid Increases Intracellular Tetrahydrobiopterin Via a Chemical Stabilization and Potentiates Nitric Oxide Synthesis in Endothelial Cells | p. 265 |
| The Redox Status of Bound Pterin Cofactor Determines whether eNOS Produces NO or Superoxide Anion: [[superscript 3]H]-BH[subscript 4] Binding Studies Provide Insights into Vascular Pathophysiology | p. 271 |
| Sepiapterin Reductase Deficiency: Molecular Analysis in a New Case Presenting with Neurotransmitter Deficiency Without Hyperphenylalaninemia | p. 277 |
| Molecular Basis of DOPA-Responsive Dystonia | p. 285 |
| Human Nigrostriatal Dopamine Neurons Express Low Levels of GTP Cyclohydrolase I mRNA | p. 291 |
| Immunosuppressive Effects of the 4-Amino Analogue of Tetrahydrobiopterin | p. 297 |
| Tetrahydrobiopterin Responsive Hyperphenylalaninemia Without Biopterin Deficiency | p. 301 |
| The Fate of Intravenously Administered Tetrahydrobiopterin and its Implications for Heterologous Gene Therapy of Phenylketonuria | p. 305 |
| Influence of Hydrogen Peroxide (H[subscript 2]O[subscript 2]) on Pterin Homeostasis in the Depigmentation Disorder Vitiligo | p. 309 |
| Catechol-O-Methyltransferase Inhibition in the Treatment of Tetrahydrobiopterin Deficiency | p. 319 |
| Changes in Dihydropteridine Reductase (DHPR) Activity of the Occupationally Lead Exposed Workers | p. 329 |
| Clinical Utility of Pteridine Measurement in Cerebrospinal Fluid | p. 335 |
| Effect of Ascorbic Acid in Measurement of Serum Pteridine Concentration | p. 341 |
| The Effect of Tetrahydrobiopterin (BH[subscript 4]) on Sperm Motility | p. 345 |
| Tetrahydrobiopterin Deficiency in Diabetic Rats | p. 349 |
| The Effect of Tetrahydrobiopterin (BH[subscript 4]) on Diabetic Nephropathy in Streptozotocin (Stz) Induced Diabetic Rats | p. 355 |
| Determination of Sepiapterin and Sepiapterin Reductase in Human Skin | p. 359 |
| Neopterin, an Immunodiagnostic and Oxidative Stress Indicator | p. 365 |
| Role of Neopterin in Immune Monitoring in Transplant Medicine | p. 371 |
| Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines | p. 377 |
| Determination of Neopterin Levels in Gingival Crevicular Fluid (GCF) | p. 383 |
| Neopterin and Biopterin Levels in Pregnancy | p. 387 |
| Tetrahydrobiopterin (BH[subscript 4])-Mediated Neuronal Death Following Intrastriatal Kainic Acid: Implications for Parkinson's Disease | p. 393 |
| Inhibition of Oxidative Stress During Developmental Cell Death: Cellular and Behavioral Effects | p. 399 |
| The Role of Tetrahydrobiopterin (BH[subscript 4]) in Trophic Factor Withdrawal-Induced Apoptosis in PC12 Cells | p. 405 |
| Apoptotic Death of PC12 Cells Induced by Ischemia-Like Conditions is Mediated by Tetrahydrobiopterin (BH[subscript 4]) Metabolism | p. 409 |
| New Approaches Towards Inhibitors of Folate-Dependent Enzymes: Rapid Synthesis of 5-Deazapterins from Uracil Derivatives | p. 415 |
| Solid and Solution Phase Strategies for the Synthesis of Potential Inhibitors of Folate Biosynthesis | p. 421 |
| Progress Towards the Synthesis of Pyrimidodiazepine-Based Folates as Potential Inhibitors of Glycinamide Ribonucleotide Formyltransferase | p. 427 |
| Role of P53 Status on Sensitivity to Thymidylate Synthase Inhibitors and Induction of Apoptosis | p. 433 |
| Synthesis of N-[4-[(2-Amino-6-Methyl-3,4-Dihydro-4-Oxo-7h-Pyrrolo[2,3-D]-Pyrimidin-5-Yl)Methyl]Benzoyl]-L-Glutamic Acid as an Antifolate | p. 439 |
| Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3,-D]Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo[2,3-D]Pyrimidine on Antifolate Activity | p. 445 |
| Selection of Methotrexate-Resistant Lactobacillus Casei in the Presence of Folate or 5-Formyl-Tetrahydrofolate Affects the Resistance Mechanism | p. 451 |
| Molecular Mechanisms of Resistance to Antimalarial Antifolate Drug Pyrimethamine-Sulfadoxine | p. 457 |
| 5-Fluorouracil Induction of Fas and Apoptosis in Colon Cancer Patients: Relation of Clinical Outcome with Thymidylate Synthase, Mcl-1 and Rb | p. 461 |
| Synthesis of 2- or 4-Seleno Analogues of dUMP and FdUMP, and the Corresponding Nucleosides. Interactions with Mammalian Tumor Thymidylate Synthase of the Selenonucleotides and Inhibition of Tumor Cell Growth by the Selenonucleosides | p. 467 |
| Induction of Resistance to the Multi-Targeted antifolate MTA (Ly231514) in Wider Human Colon Cancer Cells | p. 473 |
| Mutational Studies of an Essential Glutamate Residue in Escherichia coli Folylpolyglutamate Synthetase with a Role in ATP Binding | p. 479 |
| Rapid Purification of the T-Protein of the Glycine Cleavage System from Rabbit Liver | p. 485 |
| Effects of Cellular Glycine on Cell Proliferation | p. 491 |
| Microarray Analysis of Genes Induced by Methionine Starvation and Growth on Different Sulfur Sources in Yeast | p. 495 |
| Gene Structure and Expression of Trichinella spiralis Thymidylate Synthase | p. 501 |
| Lack of Mutation of L1210 Thymidylate Synthase with Altered Sensitivity to FdUMP Inhibition | p. 507 |
| Enzymes of Thymidylate Biosynthesis in Trichinella pseudospiralis Muscle Larvae and Caenorhabditis elegans Dauer Larvae | p. 513 |
| Thymidylate Synthase Heterogeneity Assessed by Monoclonal Antibodies | p. 519 |
| Structure-Based Modeling of Reversed N9-C10 Bridge Antifols with Human, Pc and Tg DHFR | p. 525 |
| Regulation of Mammalian Methionine Synthase by B[subscript 12] | p. 531 |
| Biochemical Studies of Human Methionine Synthase Reductase | p. 537 |
| Model Studies for the B[subscript 12] Dependent Methyltransferases | p. 543 |
| Betaine-Homocysteine S-Methyl-Transferase (BHMT) Transcription is Inhibited by S-Adenosylmethionine (AdoMet) | p. 549 |
| Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases? | p. 557 |
| The Neuropathy of Disturbed Brain Methylation Reactions | p. 563 |
| Dopamine-Stimulated Solid-State Signaling: A Novel Role for Single-Carbon Folates in Human Attention | p. 569 |
| Is Moderate Hyperhomocysteinemia Due to Folic Acid Depletion Rather than Insufficient Dietary Intake? | p. 575 |
| C677t MTHFR Genotype is a Risk Factor for Thromboembolism: Comparison of T Allele Frequency and Homocysteine Level Between Female Thromboembolic and Non-Thromboembolic Vascular Patients, NTD Mothers and Matched NTD Controls | p. 581 |
| Molecular Bases of Hyper-Homocysteinemia Due to Inborn Errors of Folate and Cobalamin Metabolism | p. 587 |
| Vitamin B6 (PLP) and Neural Tube Defects: Is There an Association? | p. 593 |
| Erythrocyte Folate Levels in Operating Room Personnel | p. 601 |
| A Human Ileostomy Model to Determine Folate Bioavailability From Food | p. 609 |
| 12 Channel Coulometric Electrochemical Detection for the Identification of Polyglutamate Homology Amongst Cellular Folates | p. 615 |
| Gastro-Intestinal pH Modulates Facile Interconvertion of Native Formylfolates During Absorption | p. 619 |
| Control Of Folate Production in Lactic Acid Bacteria by Using Metabolic Engineering | p. 623 |
| Evidence for a Cryptic Gene that Enables E. coli to Specifically Transport Folate Analogs | p. 631 |
| Folate Transport Abnormalities and Congenital Defects | p. 637 |
| Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis | p. 643 |
| Kinetics Of Reduced Folate Carrier- and Membrane-Associated Folate Receptor-Mediated Transport of Antifolates | p. 649 |
| Cell Biology and Regulation of the Intestinal Folate Absorption Process | p. 655 |
| Participants | p. 661 |
| Index | p. 673 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
