+612 9045 4394
 
CHECKOUT
Chemical Probes in Biology : Science at the Interface of Chemistry, Biology and Medicine - Philip J. Snodgrass

Chemical Probes in Biology

Science at the Interface of Chemistry, Biology and Medicine

Hardcover Published: 1st November 2003
ISBN: 9781402076831
Number Of Pages: 243

Share This Book:

Hardcover

RRP $508.99
$352.25
31%
OFF
or 4 easy payments of $88.06 with Learn more
Ships in 7 to 10 business days

Other Available Editions (Hide)

  • Paperback View Product Published: 1st February 2014
    $227.90

Ornithine Transcarbamylase: Basic Science and Clinical Considerations, written by a leading expert on OTC, for the first time assembles and analyzes more than 40 years of basic science and clinical research. It will be the definitive resource on the topic for pediatricians, geneticists, and internists who care for patients with OTC deficiency, as well as for basic scientists and genetic researchers who study the urea cycle in mammals and the arginine biosynthetic pathway in bacteria and fungi.

Prefacep. xiii
Acknowledgmentsp. xv
Gene Structure, Regulation and Functionp. 1
Synthesis, Processing and Assemblyp. 7
Molecular and Kinetic Characteristicsp. 12
Active Site and Other Essential Residuesp. 24
Molecular Pathology of OTC Deficiencyp. 49
Animal Models of OTC Deficiency and Their Gene Therapyp. 85
Sparse-fur mutant mousep. 85
Sparse-fur[superscript ash] mutant mousep. 93
Gene therapy of mutant micep. 97
Clinical and Laboratory Findings in OTC Deficiencyp. 106
OTC deficiency in femalesp. 107
OTC deficiency in malesp. 129
Plasma amino acid levels in OTC deficiencyp. 135
Plasma amino acid levels from the literaturep. 137
Case series of OTC deficiency from the literaturep. 138
Symptoms of OTC deficiency precipitated by valproic acidp. 145
Rett syndrome and hyperammonemiap. 148
Diagnosis and Treatment of OTC Deficiencyp. 150
Diagnosisp. 150
Loading testsp. 156
Neuroimaging, EEG and pathology in liver and brainp. 158
Treatmentp. 160
Gene replacement therapyp. 163
Induction and Suppression of OTC and Urea Cycle Enzymes in Bacteria, Fungi and Mammalsp. 165
Development of fetal and neonatal OTC and urea cycle enzymesp. 179
Referencesp. 183
Indexp. 239
Biographical Notep. 243
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9781402076831
ISBN-10: 1402076835
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 243
Published: 1st November 2003
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.03
Weight (kg): 0.74