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Chemical Probes in Biology : Science at the Interface of Chemistry, Biology and Medicine - Manfred P. Schneider

Chemical Probes in Biology

Science at the Interface of Chemistry, Biology and Medicine

By: Manfred P. Schneider (Editor)

Hardcover Published: 30th November 2003
ISBN: 9781402017698
Number Of Pages: 409

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This NATO Advanced Study Institute (co-sponsored by FEBS and INTAS) under the title "Chemical Probes in Biology" was designed to summarize and disseminate recent expert knowledge regarding a deeper understanding ofbiological phenomena on a molecular level. Such scientific activities -frequently termed Bio-organic Chemistry or Chemical Biology ­ are constituting a highly interdisciplinary branch of chemistry beyond the traditional ways in which chemists and biologists have been working in the past. Thus, on this occasion we were bringing together senior experts from the disciplines of Chemistry and Biology in order to amalgamate their diverse yet basically common interests in this area. Ultimate goal was - next to an exchange of information between the two scientific cultures - the communication ofexciting possibilities in interdisciplinary research to the young scientists present. The meeting was held in the Anargyros and Korgialenios School on the Island ofSpeteses, Greece from 18-30 August 2002. The ASI was attended by a total of 91 scholars from 23 different countries. A group of 27 speakers presented a series of 34 highly stimulating, informative and educational lectures covering a broad range of topics relevant to the general theme ofthis meeting: Science at the InteifaceofChemistry, Biology and Medicine. The lectures were complemented by a total of 89 posters presented by the young scholars and a series of short lectures derived thereof This was clearly one ofthe highlites of the meeting creating a lively atmosphere of interaction and intellectual creativity - typical phenomena for the whole meeting.

Preface
Nitric Oxide: A Simple Free Radical With Complex Chemistry And Biologyp. 1
Glycopeptides And Glycoproteins: Synthetic Chemistry And Biologyp. 21
Signal Regulated Gene Expression Mediated By Transcription Factors-Members Of AP-1 And ETS/SRF Family Members: Pathways For Potential Therapeutic Interventionp. 35
Biological Activities Of The Phosphoinositide Derivatives, The Glycerophosphoinositolsp. 39
Chemical Synthesis Of All Naturally Occurring Phosphorylated Inositol Phospholipidsp. 51
Molecules Of The Inositol Phospholipid Pathway - Enzyme Assisted Synthesesp. 63
Phosphatidylinositol Specific Phospholipases C: Structure And Mechanism Of Actionp. 83
Epidermal Growth Factor Receptor Signal Trans-Activationp. 93
From Sequence To Consequence: Structural Biology And Rational Drug Design In The Age Of Genomicsp. 105
Leukocyte-Derived Myeloperoxidase Is A Physiological Nitric Oxide And Nitrite Oxidase: Functions Beyond Host Defensep. 121
Lipoic Acid, A Metabolic Antioxidant Stimulates The Insulin Signaling Pathway In Adipocytes And Counteracts Oxidative Stress and Age Related Mitochondrial And Cognitive Dysfunctionp. 137
Lipid Peroxidation And Oxidative Stress Induced Etheno- DNA Adducts In Humans And Rodentsp. 145
Brassinosteroids: A New Role Of Steroids As Bio-Signaling Moleculesp. 153
Dopamine Influence On Glutamatergic And GABAergic Interaction In Neocortex Of Awaked Brainp. 167
Study Of Human Replication Protein A By Photoaffinity Labeling Techniquep. 181
Photoaffinity Probes In Molecular Biology Of DNA Replication And DNA Repairp. 193
Neoglycoconjugates As Probes In Glycobiologyp. 207
Glycosylphosphatidylinositol Anchorsp. 227
Development Of New Synthetic Tools For The Preparation Of Biologically Active Moleculesp. 235
Quaternary Benzo[C]Phenanthridine Alkaloids-Biological Activitiesp. 245
The Fundamental Role Of Melanocortins In Brain Processesp. 255
Carbon Isotope Effects As A Tool To Study Photosynthesisp. 269
Homogeneous DNA Detectionp. 287
Unlocking Mechanisms In Gene Therapy, Stress And Proteomicsp. 297
Cationic Lipid-Nucleic Acid Complexes (Lipoplexes): From Physicochemical Properties To In Vitro And In Vivo Transfection Kitsp. 317
Multivalency In Biological Systemsp. 345
Protein Assembly To Mine The Human Genomep. 359
Synthesis Of Biologically Important Oligosaccharides And Carbohydrate Mimicsp. 371
Enzymatic Synthesis Of Carbohydrate Ligands For Natural Killer Cellsp. 379
From Tyrphostins to Iressa and Gleevec: Signal Transduction Therapy From Concept To The Patient Bedp. 391
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9781402017698
ISBN-10: 1402017693
Series: NATO Science Series II : Book 129
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 409
Published: 30th November 2003
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.03
Weight (kg): 1.7

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