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Challenges of Biological Aging : SPRINGER - Edward J. Masoro

Challenges of Biological Aging


Hardcover Published: 5th September 2000
ISBN: 9780826112774
Number Of Pages: 216

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This volume provides the non-biologist an overview of what is known about the physiological bases of aging. The author examines the many basic theories and emerging hypotheses underlying the molecular, cellular, and systemic processes involved in senescence. He addresses the normal physiological changes that characterize the aging phenotype, and also considers the role of many age-associated diseases in growing older. Masoro synthesizes a much-needed "unified theory" of biological aging to which explains how and why the body grows into the condition we call "old." This text is intended for gerontology students in training, as well as for human physiologists interested in gerontology.

What is the biological basis of aging Why does aging occur? This volume will provide the reader with an overview of what we know about the biology of aging. In a clearly written and accessible style, the author examines the many theories and hypotheses underlying the molecular, cellular, and systemic processes involved in growing older. Also considered are the many age-associated diseases and physiological changes that characterize aging, as well as interventions -- from lifestyle modifications to pharmacological treatments -- proposed to reverse age-related changes. He then synthesizes a much needed unifying concept of the biological basis of aging to help us understand why we grow old.

This book is intended for students training to become gerontologists as well as biologists not conversant in the aging field.

Aging: A Biological Puzzle
The Puzzlep. 1
Mortality Riskp. 2
Anatomical and Physiological Changesp. 3
Age-Associated Diseasesp. 4
Concept of Biological Agep. 5
Geneticsp. 6
Universalityp. 10
Demography and the Societal Challenge
Population Mortality Datap. 14
Factors Determining Population Age Structurep. 22
Societal Impact of Changing Age Structurep. 27
Need for Biomedical Breakthroughsp. 29
Why Aging Occurs
Evolutionary Biologyp. 33
History of Evolutionary Theories of Agingp. 37
Current Evolutionary Theory of Agingp. 38
Genetic Mechanisms in the Evolution of Agingp. 41
Evidence Supporting the Evolutionary Theoryp. 42
How Aging Occurs
Theories, Hypotheses, and Conceptsp. 48
Biological Basis of Aging: A Unifying Concept
Evolutionary Theory as a Guidep. 76
The Disposable Soma Theory of Agingp. 77
"Private" and "Public" Proximate Mechanisms of Agingp. 77
Unifying Conceptp. 79
The Human Aging Phenotype
Body Structure and Compositionp. 86
Skinp. 89
Musculoskeletal Systemp. 94
Nervous Systemp. 101
Cardiovascular Systemp. 124
Respiratory Systemp. 134
Renal and Urinary Systemp. 137
Gastrointestinal Systemp. 146
Endocrine and Metabolic Functionp. 153
Female Reproductive Systemp. 160
Male Reproductive Systemp. 163
Immune Systemp. 165
Thermoregulationp. 168
Possible Interventions to Retard Aging
Dietary Restriction in Rodentsp. 171
Proposed Pharmacological Interventionsp. 175
Lifestyle and Environmental Factorsp. 181
Indexp. 189
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780826112774
ISBN-10: 0826112773
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 216
Published: 5th September 2000
Country of Publication: US
Dimensions (cm): 22.91 x 15.19  x 1.6
Weight (kg): 0.49