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Cerebellar Degenerations : Clinical Neurobiology - Andreas Plaitakis

Cerebellar Degenerations

Clinical Neurobiology

By: Andreas Plaitakis (Editor)

Hardcover Published: 31st May 1992
ISBN: 9780792314905
Number Of Pages: 507

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This book encompasses basic and clinical reports on the cerebellum and its primary atrophic disorders, the cerebellar degenerations. Rapid progress has been made in undestanding the organization and function of the cerebellum at the neuronal, synaptic, and molecular level. Of particular importance has been the identification of the chemical transmitters utilized by the cerĀ­ ebellar cellular systems. More than any other brain region, the cerebellum utilizes amino acids as its main excitatory and inhibitory neurotransmitters. Excitatory amino acid transmitters, in addition to serving neuronal comĀ­ munication, may also mediate trophic and toxic effects, and as such, they may playa role in neurodegenerative processes. The cerebellar degenerations were among the first human disorders with primary system atrophy to be studied clinically and pathologically. This field of clinical cerebellar sciences, no longer confined to the previously known descriptive level, is now advancing rapidly, propelled by rapid advances in neuroimaging, immunology, and molecular biology. The advent of CT, MRI, and PET has in recent years permitted the study of central nervous system alterations in living patients, thus contributing substantially to the accuracy of the diagnosis and the classification of these disorders. The nosology of cerebellar degenerations, which has been the subject of much debate for over a century, is presently a dynamic field, with new entities being recognized and old "classic ataxias" being redefined in the light of new genetic evidence.

Contributing authors
Preface
Introduction
The cerebellum and its disorders in the dawn of the molecular agep. 1
Basic Neurosciences of the Cerebellum
Anatomy and neurochemical anatomy of the cerebellump. 11
Physiology of the cerebellump. 59
Amino acid transmitters in the adult and developing cerebellump. 89
Glutamate receptors in mammalian cerebellum: Alterations in human ataxic disorders and cerebellar mutant micep. 123
Regional and cellular distribution of glutamate dehydrogenase and pyruvate dehydrogenase complex in brain: Implications for neurodegenerative disordersp. 139
The Purkinje cell degeneration mutant: a model to study the consequences of neuronal degenerationp. 159
Clinical Neurosciences of the Cerebellum
Classification and epidemiology of cerebellar degenerationsp. 185
The cerebellar cortex and the dentate nucleus in hereditary ataxiap. 205
Clinical neurophysiology in olivopontocerebellar atrophyp. 237
Pathophysiology of ataxia in humansp. 261
Oculomotor abnormalities in cerebellar degenerationp. 281
Clinical and radiologic features of cerebellar degenerationp. 305
Etiopathogenesis of Cerebellar Disorders
Glutamate dehydrogenase deficiency in cerebellar degenerationsp. 369
Mitochondrial abnormalities in hereditary ataxiasp. 391
Cerebellar disorder in the hexosaminidase deficienciesp. 403
Dominant olivopontocerebellar atrophy mapping to human chromosome 6pp. 425
Positron emission tomography studies of cerebellar degenerationp. 443
Ataxia telengiectasia: A human model of neuroimmune degenerationp. 461
Paraneoplastic cerebellar degenerationp. 475
Indexp. 499
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792314905
ISBN-10: 0792314905
Series: Foundations of Neurology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 507
Published: 31st May 1992
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.88  x 3.81
Weight (kg): 0.86