Cell surface membranes contain a range of types of molecule of which proteins form a significant part, and which play important roles in regulating cellular activities, such as growth and differentiation. In recent years considerable advances have been made in the understanding of the structure and function of cell surface molecules, partly stimulated by the development of recombinant DNA technologies. This book provides a review of current knowledge of the molecular biology of the cell surface with particular emphasis on cell differentiation, relating the molecular properties of the cell surface to developmental biology. In addition to the central theme of cell differentiation, cell surface markers, which are useful in monitoring differentiation and cell adhesion molecules, which influence differentiation, are covered.
The book opens with two introductory chapters which provide the background information necessary to familiarize the reader with the current status of developmental biology and molecular studies of the cell surface, and includes coverage of the early embryogenesis of the mouse, teracellular matrix, the major histocompatibility complex, the immunoglobulin superfamily, growth factors, integerins, cadherins, cell-surface carbohydrates and nuclear-cell-surface interactions.
"...Cell Surface and Distribution will certainly be most valuable for the young investigator who would like to acquire very quickly some background in developmental and molecular biology..." (Trends in Genetics)
"The book will serve as a sound introduction to this topic for undergraduates and for the general reader." (Federation of European Biochemical Societies)
Biological systems; molecular architecture of the cell surface; cell surface markers and immunoglobulin superfamily; growth factors and receptors; cell adhesion molecules; cell surface carbohydrates; interaction between cell surface and nucleus.