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Cell Engineering : Apoptosis - Mohamed Al-Rubeai

Cell Engineering

Apoptosis

By: Mohamed Al-Rubeai (Editor), Martin Fussenegger (Editor)

Hardcover

Published: 13th July 2004
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The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. 14. Acknowledgements We would like to thank Kurt Tidmore for preparing the illustrations. The Health Research Board of Ireland and Science Foundation Ireland are grateful acknowledged for funding. 15. References Adamo M., Roberts C. T., Jr. and LeRoith D. (1992) How distinct are the insulin and insul- like growth factor I signalling systems? Biofactors 3, 151-7. Adams T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267, 17001-5.

Understanding the Translation Reulatory Mechanisms to Improve the Efficiency and the Specificity of Protein Production by the Cell Factoryp. 1
Modulation of Gene Expression by Ribozymesp. 38
High Yield Expression of Recombinant Proteins Requiring Proteolytic Maturation: Use of the Endoprotease Furinp. 85
Baculovirus Expression Vectors: Improving Virus-Infected Cell Viability and Recombinant Protein Secretionp. 108
The Regulation of Apoptosis in Animal Cellsp. 122
Inhibition of Apoptosis in Mammalian Cell Culturep. 162
Control of Mammalian Cell Proliferation as an Important Strategy in Cell Culture Technology, Cancer Therapy and Tissue Engineeringp. 186
Development of an IRF-1 Based Proliferation Control Systemp. 220
Factors Involved in the Cell Cyle Arrest of Adult Rat Cardiomyocytesp. 239
Immortalization of Hepatocytes Through Targeted Deregulation of the Cell Cyclep. 255
Subject Indexp. 288
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9781402022166
ISBN-10: 1402022166
Series: Cell Engineering
Audience: Tertiary; University or College
Format: Hardcover
Language: English
Number Of Pages: 334
Published: 13th July 2004
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.4 x 15.6  x 1.91
Weight (kg): 1.47