MECHANISMS OF LETHAL CELL INJURY -- Chapter 1 -- Models of Toxicity Screening Using Cultured Cells /Roberta L. Grant and Daniel Acosta, Jr. -- Chapter 2 -- Apoptosis: Cellular Signaling and Molecular Mechanisms /Rosemary B. Evans and John A. Cidlowski -- Chapter 3 -- Role of Mitochondrial Injury during Oxidative Injury to Hepatocytes: Evidence of a Mitochondrial Permeability Transition by Laser Scanning Confocal Microscopy /Anna-Liisa Nieminen, Roberto Imberti, Alice K. Saylor, Samuel A. Tesfai, Brian Herman, and John J. Lemasters -- CYTOPROTECTIVE STRATEGIES -- Chapter 4 -- Glycine Cytoprotection and Inhibition of Nonlysosomal Calcium-Dependent Proteolysis during Anoxic Injury of Rat Hepatocytes /J. Christopher Nichols, Rolland C. Dickson, Steven F. Bronk, and Gregory J. Gores -- Chapter 5 -- Di-Calciphor-Dependent Protection against Cell Death due to Mitochondrial Failure /Dean P. Jones -- Chapter 6 -- Role of the Mitochondrial ATPase Inhibitor, IF1? in Cytoprotection during Ischemia in Slow and Fast Heart-Rate Hearts /William Rouslin and Charles W. Broge -- Chapter 7 -- The Discovery and Pharmacology of Tirilazad Mesylate /John M. McCall -- Chapter 8 -- The Role of Neutrophils and Reactive Oxygen Metabolites in Reperfusion Injury /Barbara J. Zimmerman and D. Neil Granger -- Chapter 9 -- The Inflammatory Response after Hepatic Ischemia /Reperfusion /Hartmut Jaeschke -- Chapter 10 -- The pH Paradox in Reperfusion Injury to Heart Cells /John J. Lemasters, John M. Bond, Ian S. Harper, Enrique Chacon, Hisayuki Ohata, Brian Herman, and Wayne E. Cascio -- Chapter 11 -- Pathophysiology of Spinal Cord Injury in a Rat Model of Decompression Sickness /Louis Marzella -- STRESS RESPONSE AND WOUND HEALING Chapter 12 -- The Stress Response and Stress Proteins /Martin E. Feder, Dawn A. Parsell, and Susan L. Lindquist -- Chapter 13 -- Cross Talk between Heat Shock and Oxidative Stress Inducible Genes during Myocardial Adaptation to Ischemia /Dipak K. Das and Nilanjana Maulik -- Chapter 14 -- Alteration in Cell Cycle Control Factors and the Induction of Oxygen-Regulated Proteins by Hypoxic Stress /Harold C. Smith, Robert L. Howell, and John W. Ludlow -- Chapter 15 -- Stress Proteins in Renal Ischemia /Shirley Hilden -- Chapter 16 -- Human Keratinocyte Migration Involves Extracellular Matrix and Soluble Factors /David T. Woodley, John D. Chen, Elizabeth Shim, Janice P. Kim, Jean-Christophe Lapiere, and Christina Peavey -- Chapter 17 -- Endothelial Cell Signaling during Wound Healing /Lewis H. Romer -- PRESERVATION OF CELLS AND ORGANS Chapter 18 -- Development and Optimization of Preservation Solutions /James H. Southard -- Chapter 19 -- Hypoxia, Free Radicals, and Reperfusion Injury Following Cold Storage and Reperfusion of Livers for Transplantation /Ronald G. Thurman, Wenshi Gao, Henry D. Connor, Sigrid Bachmann, Robert T. Currin, Ronald P. Mason, and John J. Lemasters -- Chapter 20 -- Cellular Injury Associated with Organ Cryopreservation: Chemical Toxicity and Cooling Injury /Gregory M. Fahy, Carla da Mouta, Latchezar Tsonev, Bijan S. Khirabadi, Patrick Mehl, and Harold T. Meryman -- Index.