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Cell Adhesion Molecules in Health and Disease : Falk Symposium - W. Reutter

Cell Adhesion Molecules in Health and Disease

Falk Symposium

By: W. Reutter (Editor), D. Schuppan (Editor), Rudolf Tauber (Editor), M. Zeitz (Editor)

Hardcover

Published: 31st October 2003
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Cell-cell and cell-matrix interactions are of fundamental importance for the development and the maintenance of tissues and organs in multicellular organisms. Adhesive processes are mediated and controlled by an increasingly large and complex number of cell adhesion molecules that are anchored to the cell surface membrane by transmembrane domains. According to their structural and functional features, cell adhesion molecules have been classified into at least four major families: the integrins, selectins, cadherins and members of the immunoglobulin superfamily. Apart from linking cells to each other or to components of the extracellular matrix, cell adhesion molecules function also as receptors that interact via their cytoplasmic domain with numerous signalling molecules including protein kinases and phosphatases, G-proteins, or proteins of the beta-catenin/armadillo family. Cell adhesion molecules can activate various signalling pathways and as a consequence play a crucial role in the regulation of cell differentiation, proliferation, migration and apoptosis. During the last decade it has been recognized that acquired as well as inherited defects of cell adhesion molecules and adhesion-linked signalling molecules are the molecular basis of various types of disease including cancer, infectious and inflammatory disease, connective tissue disorders or blistering disease.
This book is the proceedings of a Falk Workshop held in Berlin, Germany, on January 23-24, 2003, which brought together experts in different fields of research to stimulate the transfer of findings from basic research to clinical application. Section I focuses on cell adhesion molecules of the liver and their role in hepatocarcinogenesis and inflammatory liver disease. Section II deals with infection and fibrosis and with transforming growth factor beta (TGF-beta). Morphogenesis, cell migration and inflammation are the subject of Section III with a focus on the role of integrins in blood cell-endothelial interactions. In Section IV the importance of cell adhesion molecules for cancer and their role as potential target for cancer therapy will be discussed.

List of principal contributorsp. vii
Prefacep. ix
CAMs As General Mediators of Biological Responses
Specific adhesion molecules mediate lymphocyte recruitment to the inflamed and malignant human liverp. 3
Tetraspanin functions and microdomain organizationp. 26
Infection and Fibrosis
Cell adhesion and growth factor co-signallingp. 39
Double-transgenic mice with liver-specific conditional expression of TFG-[beta subscript 1]: characteristics of a new liver fibrosis modelp. 45
Platelet--endothelial cell adhesion molecule (PECAM-1) in liver inflammation--in-vivo and in-vitro studiesp. 54
TGF-[beta] signalling in transdifferentiating hepatic stellate cellsp. 66
Morphogenesis, Migration, Inflammation
Multifunctional carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1)p. 83
Leucocyte--endothelial cell interaction in hepatic ischaemia/reperfusion injuryp. 93
Compartmentalized migration of mucosal B cells: normal dichotomy and disease-associated alterationsp. 99
Adhesion of monocytes and neutrophils to vascular endothelium in atherosclerosis and inflammationp. 115
Role of the integrin [alpha subscript 1]-subunit in post-ligand eventsp. 120
Targeting cell adhesion molecules and cell signalling pathways in inflammatory bowel diseasesp. 133
Cancer and Cancer Therapy
[beta]-Catenin in Wnt signalling and cancerp. 145
Growth-regulatory autocrine and paracrine signalling pathways as potential therapeutic targets in human hepatocarcinogenesisp. 154
Targeting cancer with viral vectorsp. 171
Indexp. 183
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780792387862
ISBN-10: 0792387864
Series: Falk Symposium
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 196
Published: 31st October 2003
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 1.91
Weight (kg): 0.52