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Cataract : Biochemistry, Epidemiology and Pharmacology - John Harding


Biochemistry, Epidemiology and Pharmacology

Hardcover Published: 31st May 1991
ISBN: 9780412360503
Number Of Pages: 334

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Cataract is the major cause of blindness in man throughout the world. It is usually dealt with by surgery but surgery is expensive and may lead to other ocular damage. Apart from surgery one might hope to prevent cataracts or to cure them, but these approaches require a much greater understanding of the structure and metabolism of the lens and of its weaknesses and strengths. The emphasis of this book is on recent findings. The first chapter deals with the normal lens and its structure, cellular composition, metabolism and proteins. In the following chapter the ageing of the lens will be discussed, and the third chapter discusses the epidemiology of cataract emphasizing the size of the problem of cataract and the associated risk factors. Surgery is discussed briefly but without detailed discussion of recent changes in surgical procedure. That is followed by a chapter on experimental cataracts and related in vitro studies. The studies of human cataracts are discussed in chapter 5. The last chapter deals with the prevention of cataract and its delay by anti-cataract agents. There have been advances in this area recently and there is the promise of an effective therapeutic treatment soon.

Industry Reviews

The book is readily read and should become widely known - Acta Ophthalmological ; excellent review - The Lancet ; A nicely judged and readable living history - New Scientist ; I recommend this book to anyone who has an interest in either cataract or just the normal workings of the lens - Current Eye Research ; extremely useful as a source of reference for both undergraduates and postgraduates with a special interest - Opthal Physio

Part 1 The normal lens: transparency; metabolism; crystallins; membrane and cytoskeletal proteins. Part 2 The ageing lens: physical changes; metabolic changes; changes to crystallins; changes to plasma membranes and cytoskeleton. Part 3 The epidemiology of cataract: the size of the problem; prevalence and incidence; case-control studies; diabetes; diarrhoe, malnutrition, poverty and sunlight; renal failure; hypertension and diuretics; myopia; miscellaneous risks; cataract and mortality. Part 4 Experimental opacification of the lens in vivo and in vitro: sugar cataract; radiation cataract; cynate, isocyanates, urea and cataract; steroid-induced cataract; selenite-induced cataract; genetic cataracts; calcium and opacification; oxidation and opacification; phase seperation opacification (cold cataract); miscellaneous cataracts; synergistic cataracts; common pathways to cataract. Part 5 Human cataract: physical changes; metabolic changes; changes to crystallins; changes to membranes; common pathways to human cataract. Part 6 Prevention and therapy: prevention by eliminating causes; anti-cataract agents.

ISBN: 9780412360503
ISBN-10: 0412360500
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 334
Published: 31st May 1991
Publisher: Chapman and Hall
Country of Publication: GB
Dimensions (cm): 23.5 x 15.5  x 2.0
Weight (kg): 1.47

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