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Cardiovascular Specific Gene Expression : DEVELOPMENTS IN CARDIOVASCULAR MEDICINE - P. A. F. M. Doevendans

Cardiovascular Specific Gene Expression

DEVELOPMENTS IN CARDIOVASCULAR MEDICINE

By: P. A. F. M. Doevendans (Editor), Robert S. Reneman (Editor), Marc van Bilsen (Editor)

Hardcover Published: 30th April 1999
ISBN: 9780792356332
Number Of Pages: 330

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Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made.

List of Contributors
Preface
Cardiology approaching the year 2000. A clinician's look at molecular cardiologyp. 1
Cardiovascular specific gene expression
The transcriptional building blocks of the heartp. 7
A cardiac-specific troponin I promoter. Distinctive patterns of regulation in cultured fetal cardiomyocytes, adult heart and transgenic micep. 17
Mice deficient in muscle LIM protein (MLP) reveal a pathway to dilated cardiomyopathy and heart failurep. 27
Regulation of endothelial cell specific receptor tyrosine kinase gene expression during development and diseasep. 35
Smoothelins: one gene, two proteins, three muscle cell types .... so farp. 49
Transcription regulation
Regionalization of transcriptional potential in the myocardium: 'cardiosensor' transgenic micep. 67
Human troponin genes: transcriptional regulation and chromosomal organizationp. 75
Retinoid signaling: insight from genetically engineered micep. 87
Ventricular expression of the atrial regulatory myosin light chain genep. 99
Expression of rat gap junction protein connexin 40 in the heartp. 117
Ion channels and gap junction
Sympathetic regulation of cardiac delayed rectification: relationship to cardiac arrhythmiasp. 125
The sarco(endo)plasmic reticulum Ca[superscript 2+] pumps in the cardiovascular systemp. 139
Potassium channels; genes, proteins, and patientsp. 151
Expression of Cx43 in cardiac and aortic muscle cells of hypertensive ratsp. 161
Genetic engineering and cardiac ion channelsp. 171
Intracellular signaling
Receptor tyrosine kinase signaling in vasculogenesis and angiogenesisp. 179
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792356332
ISBN-10: 0792356330
Series: DEVELOPMENTS IN CARDIOVASCULAR MEDICINE
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 330
Published: 30th April 1999
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 24.77 x 16.51  x 1.91
Weight (kg): 0.75