Cardiovascular Disease in Diabetes

A. Evaluation of Cardiovascular Problems in Diabetes.- 1. Assessment of cardiac function in diabetic patients by impedance cardiography.- 2. Early diastolic dysfunction of left ventricle and its relation to pathologic finding in patients with diabetes mellitus.- 3. Radionuclide assessment of left ventricular function in middle-aged asymptomatic non-insulin-dependent diabetic patients.- 4. Usefulness of exercise Tl-201 myocardial scintigraphy to detect asymptomatic heart disease in diabetic patients.- 5. Autonomic function test assessed by ambulatory ECG in diabetes.- 6. Diabetic albuminuria and ischemic heart disease.- 7. Prognostic significance of treadmill exercise stress test in diabetic patients without cardiovascular signs.- 8. Coronary artery bypass grafting in the diabetic heart: Myocardial tolerance during surgery and late result.- B. Interactions of Diabetes and Hypertension.- 9. The influence of diabetes on myocardial contractility and energetics in spontaneously hypertensive rats.- 10. Hypertensive-diabetic cardiomyopathy in rats.- 11. Combined effects of hypertension and diabetes on myocardial contractile proteins and cardiac function in rats 95.- 12. Diabetes does not accelerate cardiac hypertrophy in spontaneously hypertensive rats (SHR).- 13. A close correlation of fasting insulin levels to blood pressure in obese children.- C. Pathophysiological Aspects of Cardiovascular Dysfunction in Diabetes.- 14. Cardiovascular involvements in a new spontaneously diabetic (WBN/Kob) rat.- 15. Biochemical and morphologic alterations in cardiac myocytes in streptozotocin-induced diabetic rats.- 16. Diabetes prolongs the action potential duration in rat ventricular muscle probably via enhanced calcium current.- 17. Increases in voltage-sensitive calcium channel of cardiac and skeletal muscle in streptozotocin-induced diabetic rats.- 18. Changes in cell morphology, [Ca2+]i and pHi during metabolic inhibition in isolated myocytes of diabetic rats using dual-loading of fura-2 and BCECF.- 19. Abnormal phosphorylation: Cause of reduced responsiveness to isoproterenol in diabetic heart.- 20. Electron microscopic cytochemical studies on ATPase and acid phosphatase activities of cardiac myocytes in streptozotocin induced diabetic rats.- 21. Myocardial isoenzyme distribution in chronic diabetes: Comparison with isoproterenol-induced chronic myocardial damage.- 22. In vivo 31-NMR spectroscopic investigation of myocardial energy metabolism in alloxan-induced diabetic rabbits.- 23. Characterization of beta-adrenoceptors in sinoatrial node and left ventricular myocardium of diabetic rat hearts by quantitative autoradiography.- 24. Effects of zinc deficiency on heart catecholamine concentrations in normal and diabetic rats.- 25. Atrial natriuretic peptide levels in plasma and atrial auricles of the non-obese diabetic (NOD) mouse.- D. Pharmacological and Therapeutic Aspects of Diabetic Heart.- 26. Effects of beta-adrenoceptor blocking agents on myocardium isolated from experimentally diabetic rats.- 27. Effects of autonomic agents on isolated and perfused hearts of streptozotocin-induced diabetic rats.- 28. Insulin-like actions of vanadyl sulfate trihydrate in streptozotocin- diabetic rats.- 29. Different cardiac effects of hypoglycaemic sulphonylurea compounds.- 30. Reversibility of diabetic cardiomyopathy by therapeutic interventions in mild diabetes.- 31. Improvement of myocardial function and metabolism in diabetic rats by the carnitine palmitoyltransferase inhibitor etomoxir.- 32. Abnormal mitochondrial oxidative phosphorylation of ischaemic and reperfused myocardium reversed by L-propionyl-carnitine.