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Cardiac Electrophysiology Methods and Models - Daniel C. Sigg

Cardiac Electrophysiology Methods and Models

By: Daniel C. Sigg (Editor), Paul A. Iaizzo (Editor), Yong-Fu Xiao (Editor), Bin He (Editor)

Paperback

Published: 17th September 2010
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Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.

From the reviews:

"Written by clinicians who have had a major impact on arrhythmia research, this book explains important methods and protocols that have been used in electrophysiology research. ... It is intended for health science students, physicians in training, and practicing cardiologists, especially electrophysiologists and those interested in pursuing a career in electrophysiology. ... This book nicely illustrates how skillful and thoughtful research at the cellular level can lead to new innovation that can be integrated into the care of patients." (Joseph Sam Owen, Doody's Review Service, April, 2011)

Clinical Cardiac Electrophysiology: An Overview of Its Evolutionp. 1
Overview
Basic Cardiac Electrophysiology: Excitable Membranesp. 41
Cardiac Action Potentials, Ion Channels, and Gap Junctionsp. 53
Anatomy and Physiology of the Cardiac Conduction Systemp. 73
The Electrocardiogram and Clinical Cardiac Electrophysiologyp. 91
Methods and Models
Principles of Electrophysiological In Vitro Measurementsp. 119
Cardiac Cellular Electrophysiological Modelingp. 135
Computer Modeling of Electrical Activation: From Cellular Dynamics to the Whole Heartp. 159
Detection and Measurement of Cardiac Ion Channelsp. 187
Cell Culture Models and Methodsp. 213
Isolated Tissue Modelsp. 237
Isolated Heart Modelsp. 249
Small Animal Models for Arrhythmia Studiesp. 261
Use of Large Animal Models for Cardiac Electrophysiology Studiesp. 281
Optical Mapping and Calcium Imagingp. 305
Electrophysiology of Single Cardiomyocytes: Patch Clamp and Other Recording Methodsp. 329
Invasive Electroanatomical Mapping and Navigationp. 349
Cardiac Electrophysiological Imaging: Solving the Inverse Problem of Electrocardiographyp. 357
Traditional Electrophysiological Mappingp. 375
Multi-channel System for Analysis of Cardiac Rhythmicity and Conductivity In Vitrop. 395
Cardiac CT/MRI Imaging for Electrophysiologyp. 419
Putting It All Together
Introduction to Translational Researchp. 441
Clinical Perspective: Electrophysiology in the Young and Patients with Congenital Heart Diseasep. 457
Indexp. 479
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9781441966575
ISBN-10: 1441966579
Audience: Professional
Format: Paperback
Language: English
Number Of Pages: 492
Published: 17th September 2010
Publisher: Springer-Verlag New York Inc.
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 2.67
Weight (kg): 0.77