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Cardiac Allograft Rejection - G. William Dec

Cardiac Allograft Rejection

By: G. William Dec (Editor), Jagat Narula (Editor), Manel Ballester (Editor), Ignasi Carrio (Editor)

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Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy. This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

List of Contributors
Histocompatibility Antigens and Transplant Rejectionp. 3
Immunology of Cellular and Humoral Rejection after Cardiac Transplantationp. 21
Immunobiology of Chronic Cardiac Allograft Rejectionp. 49
Inflammatory Cell Infiltration, Cytokines and Mechanisms of Myocyte Necrosis in Cardiac Transplant Rejectionp. 65
Apoptosis in Cardiac Transplant Rejectionp. 89
Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomesp. 101
Strategies for the Induction of Allograft Tolerancep. 127
Xenotransplantation: Hyperacute and Delayed Xenograft Rejectionp. 153
Endomyocardial Biopsy Diagnosis of Cardiac Allograft Rejectionp. 177
Clinical Diagnosis and Management of Cardiac Allograft Rejection and Maintenance Immunosuppressionp. 197
New Immunosuppressive Agentsp. 233
Treatment of Acute Vascular Rejection in Cardiac Allograftsp. 267
Evolution of Noninvasive Testing for the Detection of Cardiac Allograft Rejectionp. 287
Echocardiographic Diagnosis of Acute Allograft Rejectionp. 299
The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejectionp. 321
Targets for Radionuclide Imaging of Cardiac Allograft Rejectionp. 341
Detection of Apoptosis for the Noninvasive Diagnosis of Cardiac Allograft Rejectionp. 349
Detection of Cardiac Allograft Rejection by Noninvasive Imaging of Lymphocyte Infiltrationp. 359
Detection of Cardiac Allograft Rejection by Targeting Expression of Accessory Molecules on Cardiac Myocytesp. 367
Algorithms for Management of Heart Transplant Rejection Based on Surveillance of Myocardial Damage by Antimyosin Antibody Imagingp. 381
Color Platesp. 399
Subject Indexp. 423
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792373292
ISBN-10: 0792373294
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 434
Published: September 2001
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 0.93