It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo- therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation.
Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome.
I. Advances in Staging and Primary Treatment.- 1. Magnetic Resonance Imaging of Head and Neck Cancer.- 2. Diagnostic Imaging in the Diagnosis of Malignant Invasion of the Carotid Artery: Ultrasound, Computed Tomography, Magnetic Resonance Imaging.- 3. Craniofacial Resection for Tumors of the Ethmoid and Superior Nasal Vault.- 4. Surgical Resection for Recurrent Nasopharynx Cancer.- 5. Advanced Basal and Squamous Cell Carcinomas of the Head and Neck.- 6. Interstitial Hyperthermia in Head and Neck Oncology.- 7. Photodynamic Therapy in the Management of Head and Neck Cancer.- II. Rehabilitation.- 8. Mechanisms for Vocal Communication Following Total Laryngectomy.- 9. Neck Dissection: Morbidity and Rehabilitation.- III. Advances in Medical Management and Chemotherapeutic Approaches.- 10. Evaluation and Medical Management of Thyroid Cancer.- 11. Chemotherapy of Patients with Recurrent Head and Neck Cancer.- 12. Combined Chemotherapy and Radiation for Unresectable Head and Neck Cancer.- 13. The Role of Induction Chemotherapy for Organ Preservation in Laryngeal Carcinoma.- IV. Basic Biology and Etiology.- 14. Methodology and Clinical Applications of Cellular DNA Content Parameters Determined by Flow Cytometry in Squamous Cell Cancers of the Head and Neck.- 15. Head and Neck Tumor Immunology II. Humoral Immunity.- 16. Etiologic Considerations for Head and Neck Squamous Cancers.
Series: Studies of Classical India
Number Of Pages: 292
Published: 31st July 1990
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6
Weight (kg): 0.61