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Cannabinoids : Neuroscience Intelligence Unit - Vincenzo di Marzo


Neuroscience Intelligence Unit

By: Vincenzo di Marzo (Editor)

Hardcover Published: 29th June 2004
ISBN: 9780306482281
Number Of Pages: 216

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The 21st century will witness the unprecedented marketing of therapeutic drugs developed from cannabinoids and the endocannabinoid system. Cannabinoids is a timely volume, which represents a comprehensive review of the most important issues in cannabinoid research as well as those of most likely therapeutic relevance. For the first time, the multi-faceted aspects of cannabinoid chemistry, biology and medicine are presented in one volume.
Key topics of discussion:

-major families of phytocannabinoids;
-pharmacological activity of phytocannabinoids;
-interactions of phytocannabinoids with their proposed molecular target;
-components of the endocannabinoid system;
-molecular mechanisms of the endocannabinoid system;
-Physiological and pathological role of endocannabinoids;
-industrial applications of studies on the cannabinoids;
-therapeutic uses of agonists and antagonists of cannabinoids receptors. This book is a must for graduate and pre- and post-doctoral students in disciplines ranging from organic and natural product chemistry, pharmacology, biochemistry and medicine.

Prefacep. x
The Chemical Constituents of Cannabis sativa and the Endocannabinoid Systemp. 1
Pharmacology and Medicinal Chemistry of THCp. 8
Pharmacology of THCp. 9
Medicinal Chemistryp. 16
The Pharmacology and Therapeutic Potential of Cannabidiolp. 32
Receptor Interactions of Cannabidiolp. 35
Effects of CBD on Central and Peripheral Neurotransmissionp. 42
Fate of Anandamide and Palmitoylethanolamidep. 43
Anxiolytic and Antipsychotic Effectsp. 44
Anticonvulsant Effects of CBDp. 46
Neuroprotective Effect of CBDp. 53
Effects of CBD on the Production of Mediators of Inflammation and Immune Responsesp. 54
Effects of CBD on Cancer Cell Proliferationp. 59
Effects of CBD on Cytochrome P450 (CYP) Isozymesp. 60
Effects of CBD on Membrane Fluidity and Stabilityp. 61
Other Effects of CBDp. 62
Interactions between CBD and [Delta superscript 9]-THCp. 64
Structure-Activity Relationshipsp. 65
Cannabinoid Receptors and Signal Transductionp. 84
CB[subscript 1] Receptor and Signal Transduction Pathwaysp. 84
CB[subscript 2] Receptor and Signal Transduction Pathwaysp. 87
Endothelial Anandamide Receptor: Pharmacology and Signal Transduction Pathwaysp. 88
Mechanism of Receptor-Mediated G Protein Couplingp. 88
Endocannabinoidsp. 98
Discovery of the Endocannabinoidsp. 99
Quantitative Analysis of Endocannabinoids in Mammalsp. 100
Biosynthesis, Action and Inactivation of Endocannabinoidsp. 101
Possible Physiological and Pathological Functions of Endocannabinoids in the CNS--An Overviewp. 113
Endocannabinoids: Relax, Eat, Rest, Forget and Protectp. 118
Chemistry and Structure Activity Relationships for Tetrahydrocannabinols and Endocannabinoidsp. 131
Endocannabinoidsp. 138
Pyrazole Based Antagonistsp. 141
Cannabinoids and Medicine: Eating Disorders, Nausea and Emesisp. 147
Endocannabinoids and the Physiological Regulation of Appetite and Body Weightp. 147
Disorders of Appetite and Body Weightp. 150
Obesityp. 150
Cachexia, Anorexia and Malnutrition in Diseasep. 152
Nausea and Emesisp. 155
Cannabinoids and Medicine II: The Role of Cannabinoids in Multiple Sclerosis and Neuronal Damagep. 161
Multiple Sclerosisp. 162
Head Injury and Strokep. 167
Glaucomap. 169
Parkinson's Diseasep. 170
Huntington's Diseasep. 171
Motor Neuron Diseasesp. 172
Alzheimer's Diseasep. 173
Endocannabinoids and Related Fatty Acid Derivatives in Pain Modulation: Behavioral, Neurophysiological and Neuroanatomical perspectives on Cannabinoid Antinociceptionp. 181
Functional Significance of a Cannabinoid Transmitter Systemp. 181
Subtypes of Cannabinoid Receptorsp. 182
Endocannabinoidsp. 182
Cannabinoid Receptor Pharmacologyp. 183
Antinociceptive Effects of Cannabinoidsp. 183
Cannabinoid-Induced Suppression of Nociceptive Transmissionp. 183
Spinal and Peripheral Cannabinoid Antinociceptive Mechanismsp. 184
Evidence for Endocannabinoid Modulation of Nociception at the Supraspinal Levelp. 187
Role of Other Endocannabinoids and Related Fatty Acid Derivativesp. 189
Localization of Cannabinoid Receptors and mRNAp. 190
Cannabinoid Receptor Distribution on Central Terminals of Primary Afferentsp. 193
Endocannabinoids and Alcohol Drinking Behaviorp. 205
Endocannabinoids and Brain Reward Mechanismsp. 205
Endocannabinoids As Regulators of Alcohol Preferencep. 206
Age-Dependence of Alcohol Preference and Endocannabinoid Signaling in Micep. 207
Endocannabinoids and Alcohol-Withdrawalp. 209
A New Hypothesisp. 209
Indexp. 213
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780306482281
ISBN-10: 0306482282
Series: Neuroscience Intelligence Unit
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 216
Published: 29th June 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 23.77 x 15.7  x 1.96
Weight (kg): 0.55