Cancer Treatment and Research

By: Asad Bashey, Edward D. Ball, Asad Bashey M. D. Ph. D. (Editor)

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Hardcover | 28 February 2002

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232 Pages

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24.77 x 16.51 x 1.91

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Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of haematopoietic transplantation. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of haematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumour immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use. This text should provide both practitioners and academic clinicians with a better understanding of underlying concepts, current methodologies and results obtained by the pioneering centres in this rapidly evolving field.

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Non-Fiction Medicine Surgery Transplant Surgery Clinical & Internal Medicine Haematology Diseases & Disorders Oncology Surgical Oncology Science Biology, Life Sciences Life Sciences in General

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Published: 30th October 2012

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Contributors
Preface
Development of allogeneic hematopoietic stem cell transplantation (HSCT)	p. 1
Immunosuppression with limited toxicity: the characteristics of nucleoside analogs and anti-lymphocyte antibodies used in non-myeloablative hematopoietic cell transplantation	p. 39
Mobilization of allogeneic peripheral blood progenitor cells	p. 51
Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies	p. 79
Combined use of autografting and non-myeloablative allografting for the treatment of hematologic malignancies and metastatic breast cancer	p. 101
Non-myeloablative hematopoietic stem cell transplantation (NST) in the treatment of human malignancies: from animal models to clinical practice	p. 113
Non-myeloablative allogeneic hematopoietic transplantation and induction of graft-versus-malignancy	p. 137
Outpatient allografting in hematologic malignancies and nonmalignant disorders - applying lessons learned in the canine model to humans	p. 149
Non-myeloablative transplants for congenital diseases	p. 177
Index	p. 213
Table of Contents provided by Blackwell. All Rights Reserved.

Cancer Treatment and Research

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Hardcover

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