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Cancer Stem Cell Resistance to Targeted Therapy : Resistance to Targeted Anti-Cancer Therapeutics - Cristina Maccalli

Cancer Stem Cell Resistance to Targeted Therapy

Resistance to Targeted Anti-Cancer Therapeutics

By: Cristina Maccalli (Editor), Matilde Todaro (Editor), Soldano Ferrone (Editor)

Hardcover Published: 17th June 2019
ISBN: 9783030166236
Number Of Pages: 256

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This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells.

This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

ISBN: 9783030166236
ISBN-10: 3030166236
Series: Resistance to Targeted Anti-Cancer Therapeutics
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 256
Published: 17th June 2019
Country of Publication: CH
Dimensions (cm): 23.39 x 15.6  x 1.75
Weight (kg): 0.57

Earn 513 Qantas Points
on this Book