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Cancer Oncogenes and Tumor Suppressor Genes in Human Malignancies : Cancer Treatment and Research - Christopher C. Benz

Cancer Oncogenes and Tumor Suppressor Genes in Human Malignancies

Cancer Treatment and Research

By: Christopher C. Benz (Editor), E. T. Liu (Editor)

Hardcover Published: December 2009
ISBN: 9780792319603
Number Of Pages: 382

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This volume begins by reviewing selected malignancies in which the search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and management. The remainder of the volume updates molecular mechanisms relating to select growth factor systems, oncogenes, and tumor suppressor genes introduced earlier in the disease-oriented chapters. These reviews convey the increasing fascination that comes with a greater understanding of tumor physiology. They reveal, for instance, that tumor cells can induce the secretion of paracrine growth factors from non-malignant tissues, thus usurping normal genetic programs reserved for fetal development or wound healing such as those that provide neovascularization for a malignant tissue colony. The uncovering of these subverted intercellular mechanisms, as well as the constitutively stimulated intracellular signaling pathways associated with activated oncogenes and mutated tumor suppressor genes, provide researchers with many new targets for the development of more specific and less toxic anticancer agents. A number of these novel gents are already in clinical test.

List of Contributors
Preface
Oncogenes and Tumor Suppressor Genesp. 1
Activated Oncogenes and Putative Tumor Suppressor Genes Involved in Human Breast Cancersp. 15
Oncogenes in Human Lung Cancerp. 61
Thyroid Growth Factors and Oncogenesp. 87
Growth Regulation of Human Neuroblastomap. 105
Kaposi Sarcoma: A Cytokine Responsive Neoplasia?p. 129
BCL-2: Physiology and Role in Neoplasiap. 141
Malignant Transformation by abl and BCR/ABLp. 167
The Biological and Clinical Roles of Increased Insulin Receptors in Human Breast Cancerp. 193
The Role of Fibroblast Growth Factors and Related Oncogenes in Tumor Growthp. 211
Transforming Growth Factor-alpha and its Role in Neoplastic Progressionp. 233
Growth Regulation by Transforming Growth Factor-[beta]p. 255
Signal Transduction by Receptor Tyrosine Kinasesp. 265
Involvement of G Proteins, Cytoplasmic Calcium, Phospholipases, Phospholipid-Derived Second Messengers, and Protein Kinases in Signal Transduction from Mitogenic Cell Surface Receptorsp. 281
Fos and Jun: Inducible Transcription Factors Regulating Growth of Normal and Transformed Cellsp. 301
DNA Binding by the myc Oncoproteinsp. 313
Normal and Malignant Growth Control by p53p. 327
Nucleoside Diphosphate Kinases, nm23, and Tumor Metastasis: Possible Biochemical Mechanismsp. 345
Angiogenesis: A Mechanism by Which Oncogenes and Tumor Suppressor Genes Regulate Tumorigenesisp. 359
Indexp. 373
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792319603
ISBN-10: 0792319605
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 382
Published: December 2009
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 16.51  x 2.54
Weight (kg): 0.7