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Cancer Imaging with Radiolabeled Antibodies : Cancer Treatment and Research - David M. Goldenberg

Cancer Imaging with Radiolabeled Antibodies

Cancer Treatment and Research

By: David M. Goldenberg (Editor)

Hardcover

Published: December 2009
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' It is recommended for laboratory investigators who seek detailed information on many of the important issues in radioimmunodetection research and for clinical investigators active in this area, who will benefit from comparing a variety of viewpoints on the major problems that still need to be solved.' Cancer Cells, 3:1, 1991

` It is recommended for laboratory investigators who seek detailed information on many of the important issues in radioimmunodetection research and for clinical investigators active in this area, who will benefit from comparing a variety of viewpoints on the major problems that still need to be solved.' Cancer Cells, 3:1, 1991

I. Historical and Theoretical Perspectives.- 1. Clinical radioimmunodetection: The second decade.- 2. Antibody targeting: Theoretical considerations.- II. Model Systems.- 3. Experimental model systems for antibody targeting and radioimmunodetection.- 4. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy.- 5. Physiology of monoclonal antibody accretion by tumors.- 6. Intraperitoneal delivery of monoclonal antibodies.- III. Radiochemistry.- 7. Chelates and antibodies: Current methods and new directions.- 8. Radiolabeling antibodies via the cyclic anhydride of DTPA - Experiences of 5 years.- 9. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies.- 10. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate.- 11. Novel bifunctional linkers for antibody chelation with radiometals.- 12. Labeling of anti-tumor antibodies and antibody fragments with Tc-9m.- IV. Clinical Studies.- 13. Requirements for the use of radioimmunodetection of cancer in clinical practice.- 14. In-vivo antibody imaging for the detection of human tumors.- 15. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer.- 16. Tumor targeting with monoclonal antibody B72.3: Experimental and clinical results.- 17. Antibody imaging of endocrine tumors.- 18. Diversity of the human immune response to clinically used murine monoclonal antibodies.- V. New Approaches.- 19. Antibody lymphoscintigraphy.- 20. Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor.- 21. Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas.- 22. Anti-antibody enhancement of tumor imaging.

ISBN: 9780792306313
ISBN-10: 0792306317
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 468
Published: December 2009
Publisher: SPRINGER VERLAG GMBH
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 2.69
Weight (kg): 0.86