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Cancer Chemotherapy : Concepts, Clinical Investigations and Therapeutic Advances :  Concepts, Clinical Investigations and Therapeutic Advances - Franco M. Muggia

Cancer Chemotherapy : Concepts, Clinical Investigations and Therapeutic Advances

Concepts, Clinical Investigations and Therapeutic Advances

By: Franco M. Muggia (Editor)

Hardcover

Published: December 2009
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Focus of these articles is on new advances such as the current status of trimetrexate, the ability to modulate the action of alkylating agents and fluorinated pyrimidines to achieve greater sensitivity, and the genetics of multidrug resistance in human tumors. Also addressed are the role of the nurs

I. Concepts.- 1. Alkylating agents: Mechanisms and modulation.- 2. Reduced folates and fluoropyrimidine antitumor efficacy.- 3. Laboratory aspects of multidrug resistance.- II. Initial clinical investigations.- 4. Multidrug resistance: clinical findings and implications.- 5. Current status of trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties.- 6. Daunomycin and doxorubicin LYM-1-drug conjugates for the treatment of malignant lymphomas.- 7. Phase I trials: Role of the nurse investigator.- III. Therapeutic advances.- 8. The role of chemotherapy in the treatment of squamous cell tumors of the esophagus.- 9. Systemic chemotherapy of transitional cell carcinoma of the urothelium.- 10. Nasopharyngeal cancer, undifferentiated type: The medical oncologist's viewpoint.- 11. Primary central nervous system lymphomas.

ISBN: 9780898383812
ISBN-10: 0898383811
Series: Cancer Treatment and Research
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 238
Published: December 2009
Publisher: Kluwer Academic Publishers
Country of Publication: US
Dimensions (cm): 23.5 x 15.5  x 1.5
Weight (kg): 1.19