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Cancer Chemotherapy & Biotherapy : Principles and Practice - Chabner Longo

Cancer Chemotherapy & Biotherapy

Principles and Practice


Published: 1st December 2010
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Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations.

This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised.

A companion website includes the fully searchable text and an image bank.

Basic Principles Of Cancer Treatment
Clinical Strategies for Cancer Treatment: The Role of Drugs
Target Identification and Drug Discovery
Clinical Drug Development and Approval for Marketing
Principles of Pharmacokinetics
Special Aspects of Brain Tumor Chemotherapy
Barriers to Drug Delivery
Cytotoxic Agents
Cytidine Analogues
Purine Analogues
Antimitotic Drugs
Alkylating Agents (Including Methylating Agents)
Platinum Analogues
Antitumor Antibiotics (Including Bleomycin)
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors: Anthracyclines
Topoisomerase II Inhibitors: Etoposide, Teniposide
Molecularly Targeted Therapies
Proteosome Inhibitors
HDAC Inhibitors
Differentiating Agents (Retinoids)
Arsenic Trioxide
Monoclonal Antibodies: Discovery & Development
Anti-angiogenic Agents (Including MonAB)
Anti-EGFR Therapies (Including MonAB)
Anti-her 2 Therapies
Intracellular Signal Inhibitors (bcr-abl)
Signal Transduction Inhibitors in Development
Inhibitors of the PI3k Pathway & Mitotic Kinase
Immunologic Agents
Interferon and Cytokines
Adoptive Cellular Therapies
Immuno-modulatory Drugs (IMIDS, Anti-CTLA4)
Hormonal Therapy
Hormonal Therapy of Breast Cancer
GNRH Agonists and Anti-Androgens
Supportive Care
Pain Management in Cancer Patients
Colony Stimulating Factors
Anti-nausea Medications
Bone Loss Modulators
Intravenous Access and Catheter Management
Monitoring for Late Side Effects of Chemotherapy
Table of Contents provided by Publisher. All Rights Reserved.

ISBN: 9781605474311
ISBN-10: 1605474312
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 848
Published: 1st December 2010
Country of Publication: US
Dimensions (cm): 28.58 x 22.23  x 3.81
Weight (kg): 2.14
Edition Number: 5
Edition Type: Revised