In anticipation of the opening of the H. Lee Moffitt Cancer Center and Research lnstitut~ on the campus of the University of South Florida, an international symposium, "The First Annual H. Lee Moffitt Symposium on Cancer Biology and Therapeutics" was held in Tampa, Florida on January 20-22, 1986. In this first symposium we decided to present a broad-based series of topics dealing with the major issues in the field of cancer. These topics ranged from the biochemistry of the cancer cell to the design of antineoplastic agents, through tumor cell heterogeneity, treatment of ltuman neoplasms to immunological aspects of cancer biology and tr~atment. The speakers chosen represented individuals of international acclaim who are very active in the area of cancer research and treatment. The symposium brought together scien tists/physicians from six nations including Austria, Canada, France, Hungary, West Germany, and of course, the United States. The congeniality of the participants promoted the friendly exchange of knowledge which, it is hoped, will greatly hasten the time when successful management of human cancer will become routine. Future symposia in this series will be highly focused and will deal with a single facet of this vast field of cancer research and treatment. Joseph G. Cory, Editor Andor Szentivanyi, Editor University of South Florida, 1986 V ACKNOWLEDGMENTS This volume presents the Proceedings of the H. Lee Moffitt International Syn~osium on Cancer Biology and Therapeutics which was held in Tampa, Florida on January 20, 21, and 22, 1986.
Section I Biochemistry of the Cancer Cell and Selectivity of Drug Action.- Biochemical Strategy of Cancer Cells and the Targeting of Chemotherapy with Tiazofurin, Acivicin, and Dipyridamole.- The Biological Bases for the Design of Anticancer Agents.- Biochemistry of Methotrexate: Teaching an Old Drug New Tricks.- Section II Biological and Clinical Implications of Tumor Cell Heterogeneity and Metastases.- Biological and Clinical Implications of the Stem Cell Concept in Human Malignancy.- Membrane Properties of Lewis Lung Tumor Cells with "Low" and "High" Metastatic Capacity: Anti-metastatic Effect of a Glycosaminoglycan Biosynthesis Blocking Agent 5-Hexyl-2?-deoxyuridine (HUdR).- Implications of Therapy-induced Genetic/Epigenetic Modulations of Tumor Progression and Tumor Cell Heterogeneity for the Treatment of Cancer.- Section III Approaches to the Treatment and Diagnosis of Cancer.- Site-directed Combination Chemotherapy.- Sugar Analogs and 5-Fluorouridine in Combination Chemotherapy.- New Strategies for the Improvement of Alkylating Antitumor Agents.- Application of Proton Nuclear Magnetic Resonance to Tumor Biology.- Section IV Clinical Advances and Problems in the Treatment of Human Tumors.- Relationships of Cell Biology to Therapy in Childhood Leukemia.- Clinical Cancer Treatment and Drug Resistance: The Interface of the Clinic and the Laboratory.- Section V Induction, Prevention, and Modulation of Cancer.- Nitrosamines and Human Cancer: Some Implications of Basic Research.- Molecular Mechanisms in Protection Against Carcinogenesis.- Antineoplastic Agents and Cancer Cell Differentiation.- Section VI Immunological Aspects of Neoplasia.- A Reappraisal of Cytotoxic Lymphocytes in Human Tumor Immunology.- From Tumor Relapse Prevention to Tumor Induction Prevention.- Participants.