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Calcium : The Molecular Basis of Calcium Action in Biology and Medicine :  The Molecular Basis of Calcium Action in Biology and Medicine - Roland Pochet

Calcium : The Molecular Basis of Calcium Action in Biology and Medicine

The Molecular Basis of Calcium Action in Biology and Medicine

By: Roland Pochet (Editor), Rosario Donato (Editor), J. Haiech (Editor), Claus W. Heizmann (Editor), Volker Gerke (Editor)

Hardcover Published: December 2000
ISBN: 9780792364214
Number Of Pages: 732

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The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a 'key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

List of Contributors
Colourplate Section
From Genes to Drugsp. 1
Calcium Signalling in Excitable Cells
Ca[superscript 2+] Release in Muscle Cellsp. 9
Calcium Signalling in Neurons Exemplified by Rat Sympathetic Ganglion Cellsp. 27
Calcium Signalling in Non-Excitable Cells
Calcium and Plateletsp. 45
Calcium Signalling in Liver Cellsp. 73
Intercellular Calcium Signalling in "Non-Excitable" Cellsp. 95
The Ca[superscript 2+]-Mobilizing Second Messenger Cyclic ADP-Ribosep. 109
Visinin-Like Proteins (VILIPs) - Emerging Role in Cross-Talk between Cellular Signaling Pathwaysp. 129
Calcium Signalling in Extracellular Matrix
Calcium Binding to Extracellular Matrix Proteins, Functional and Pathological Effectsp. 151
The Extracellular Calcium-Sensing Receptor: Molecular Features, Distribution and Its Roles in Physiology and Diseasep. 165
Calcium Storage and Release
Regulation of Inositol 1,4,5-Triphosphate-Induced Ca[superscript 2+] Release by Ca[superscript 2+]p. 179
Calreticulin and Dynamics of the Endoplasmic Reticulum Lumenal Environmentp. 191
Ryanodine-Sensitive Calcium Release Channelsp. 205
Calcium Inhibition of Cytoplasmic Streamingp. 221
Calcium and Apoptosis
Penta-EF-Hand (PEF) Proteins and Calsenilin/DREAM: Involvement of the New EF-Hand Calcium-Binding Proteins in Apoptosis and Signal Transductionp. 245
Activation of Programmed Cell Death by Calcium: Protection against Cell Death by the Calcium Binding Protein, Calbindin-D[subscript 28k]p. 259
Calcium and Cellular Ageing
Calcium and Cellular Ageingp. 277
Calcium and Growth Factor
The Epidermal Growth Factor Receptor and the Calcium Signalp. 287
Annexinopathiesp. 307
Autoimmune Disease and Calcium Binding Proteinsp. 317
Calcium Antagonists and Calcium Sensitizersp. 333
Calcium-Binding Proteins in Type I Allergy: Elicitors and Vaccinesp. 365
Calcium Channelopathies in Nervous Systemp. 379
Calcium and Diabetesp. 401
Inherited and Acquired Disorders and Extracellular Calcium (Ca[subscript 0][superscript 2+])-Sensingp. 415
Calcium and Muscle Disease: Pathophysiology of Calpains and Limb-Girdle Muscular Distrophy Type 2a (LGMD2A)p. 443
Role of Calcium Channels in Drug Dependencep. 465
S100 Proteins and Fatty Acid Transport Are Altered in Skin Diseasesp. 477
Calcium-Binding Proteins in Degenerative and Cancer-Related Diseases of the Eyep. 493
Calcium ATPases Genes and Cell Transformationp. 505
Interaction of Dimeric S100B ([beta][beta]) with the Tumor Suppressor Protein p53: A Model for Ca[superscript 2+]-Dependent S100-Target Protein Interactionsp. 521
The Interaction of Calmodulin with Novel Target Proteinsp. 541
Liver Diseases
Type II Citrullinemia (Citrin Deficiency): A Mysterious Disease Caused by a Defect of Calcium-Binding Mitochondrial Carrier Proteinp. 565
High Calcium Concentrations, Calpain Activation and Cytoskeleton Remodeling in Neuronal Regeneration after Axotomyp. 589
Neurodegenerative Diseases
Genetic Factors ad the Role of Calcium in Alzheimer's Disease Pathogenesisp. 607
The Role of Intracellular Calcium Signaling in Motoneuron Function and Diseasep. 625
Pharmaceutical Chemistry and Drug Screeningp. 641
Calcium in Drug Screeningp. 647
Calcium Imaging, Fluorescence Microscopy, Confocal Microscopy
Imaging Intracellular Calcium in Living Tissue by Laser-Scanning Confocal Microscopyp. 661
Immature Mouse Oocyte as a Model for Imaging Nuclear Calcium Dynamicsp. 673
Single Cell Fluorescence Imaging to Investigate Signaling in Primary Cultured Neuronesp. 683
Calcium Complexities: New Fluorescence Techniques for Probing Mitochondria and Other Subcellular Compartmentsp. 697
Subject Indexp. 715
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792364214
ISBN-10: 079236421X
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 732
Published: December 2000
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 4.14
Weight (kg): 1.25

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