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Calcium Channel Pharmacology - Stefan I. McDonough

Calcium Channel Pharmacology

By: Stefan I. McDonough (Editor)

Hardcover Published: 30th November 2003
ISBN: 9780306478789
Number Of Pages: 418

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Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

Introductionp. ix
Concepts of State-Dependent Pharmacology of Calcium Channelsp. 1
Pharmacology of Ca[subscript v]1 (L-Type) Channelsp. 21
The Therapeutic Utility of Targeting Ca[subscript v]2 Channelsp. 73
Peptide Toxin Inhibition of Voltage Gated Calcium Channels: Selectivity and Mechanismsp. 95
Calcium Channel Blocking Polypeptides: Structure, Function, and Molecular Mimicryp. 143
Pharmacology of Ca[subscript v]3 (T-Type) Channelsp. 183
Cellular Functions of Calcium Channel Subtypesp. 237
Genetic Approaches to the Elucidation of Calcium Channel Functions in Vivop. 277
Calcium Channel Mutations and Associated Diseasesp. 303
Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptorsp. 331
Alternative Splicing in Voltage Gated Calcium Channelsp. 369
Indexp. 411
Table of Contents provided by Rittenhouse. All Rights Reserved.

ISBN: 9780306478789
ISBN-10: 0306478781
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 418
Published: 30th November 2003
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 3.18
Weight (kg): 1.12

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