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Breast Cancer - Biological and Clinical Progress : Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26-29, 1991 :  Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26-29, 1991 - L Dogliotti

Breast Cancer - Biological and Clinical Progress : Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26-29, 1991

Proceedings of the Conference of the International Association for Breast Cancer Research, St. Vincent, Aosta Valley, Italy, May 26-29, 1991

By: L Dogliotti (Editor), A. Sapino (Editor), G. Bussolati (Editor)

Hardcover

Published: December 2009
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The fight against breast cancer is expected to be effectively stimulated by interdisciplinary approaches and cross-fertilization between laboratory and clinical research findings. Of major importance, therefore, are meetings that promote rapid transfer to clinical applications of findings by basic scientists. This volume reports the proceedings of the 1991 Biennial Conference of the International Association for Breast Cancer Research and seeks to achieve this goal by presenting the most recent observations in the laboratory and their possible applications for diagnostic evalutions and clinical treatments. The sections of the book focus first on the oncogenes more likely involved in mammary tumorigenesis and on the polypaptide factors and steroid hormones affecting proliferation and possibly inducing carcinogenesis in breast epithelium. A section is devoted to the epidemiological studies and to the identification of risk factors; a way to select populations at higher risk and, possibly, to help in preventing the disease. Special emphasis is given to the establishment of diagnostic criteria and to the selection of prognostic factors, which must support an effective therapeutic planning. This volume is a timely update of the most recent advances in specific fields presented by basic scientists, pathologists and clinicians and will stimulate new insights and progresses leading ultimately to the control of breast cancer.

Contributors
Preface
Activation of Cellular Oncogenesp. 1
The Role of Oncogenes and Onco-Suppressor Genes in Human Breast Cancerp. 3
Expression of the MET Oncogene in Human Tumorsp. 11
c-erbB-2, a Tyrosine Kinase Growth Factor Receptor and its Role in Breast Cancerp. 23
Mammary Morphogenesis and Oncogenesp. 41
Polypeptides and Growth Factors Expressionp. 57
Interdependence of Hormones and Growth Factors in Lobulo-Alveolar Development of the Mammary Gland and Tumorigenesisp. 59
The Role of Estrogen Regulated Secreted Proteins for Growth Regulation of Human Breast Cancerp. 81
The Prolactin-Inducible Protein / Gross Cystic Disease Fluid Protein (PIP/GCDFP-15): Genetic Analysis and Hormonal Regulation of Gene Expressionp. 93
Mammary Epithelium and Stroma in Vivo and in Vitrop. 103
Role of RAS Oncogene in Human Breast Cancer: an Experimental Approachp. 105
Interactions Between Malignant and Non-Malignant Components of the Breastp. 119
Involvement of Heparanase and Extracellular Matrix-Bound Fibroblast Growth Factor in Tumor Progressionp. 137
Hormone Responsiveness and Oral Contraceptivesp. 151
Estrogen and Progesterone Receptor Activity in Breast Cancer Cellsp. 153
Oral Contraceptives and Breast Cancer: the Scope for a Hypothesis-Oriented Approachp. 169
Risk Factors; Monitoring of Breast Cancer Progression and Regressionp. 179
Benign Breast Disease: Links to Risk of Cancerp. 181
Proliferation Rate in Different Cell Types in Benign Breast Diseasep. 195
Aspects of Cell Mediated Immunity in Monitoring Breast Cancerp. 207
New Approaches to the Study of Selenium's Chemopreventive Propertiesp. 225
Biological Factors of Prognosis; The Metastatic Phenotypep. 233
Cell Kinetics as an Indicator for Prognosis and Therapyp. 235
Cathepsin D and Breast Cancer Metastasis: Biological and Clinical Significancep. 243
Diagnostic tools and prognostic factors in human breast cancer evaluated by morphological and immunohistochemical methodsp. 255
Therapeutic Strategies in Breast Cancer Treatmentp. 277
Oestrogen-Deprivation in Breast Cancer: Clinical and Experimental Observationsp. 279
Polyamines and Growth Factors as Possible Targets for Antitumor Therapy in Breast Cancerp. 291
New Diagnostic Methods and Treatment Modalities in Breast Cancerp. 301
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792316558
ISBN-10: 079231655X
Series: Developments in Oncology
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 311
Published: December 2009
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.5 x 15.5  x 2.54
Weight (kg): 1.43