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Brain Repair After Stroke - Steven C. Cramer

Brain Repair After Stroke

By: Steven C. Cramer (Editor), Randolph J. Nudo (Editor)

Hardcover Published: 31st October 2010
ISBN: 9780521515337
Number Of Pages: 292

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Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

Prefacep. vii
List of contributorsp. viii
Basic Science and Animal Studies
Motor map plasticity: a neural substrate for improving motor function after strokep. 1
Molecular mechanisms of neural repair after strokep. 11
Behavioral influences on neuronal events after strokep. 23
Post-stroke recovery therapies in animalsp. 35
Environmental effects on functional outcome after strokep. 47
Functional and structural MR imaging of brain reorganization after strokep. 57
Stroke recovery in non-human primates: a comparative perspectivep. 67
Issues in translating stroke recovery research from animals to humansp. 77
Spontaneous Stroke Recovery in Humans
Brain events in the acute period of stroke in relation to subsequent repairp. 87
Changes in cortical excitability and interhemispheric interactions after strokep. 103
Human brain mapping of the motor system after strokep. 113
Recovery from aphasia: lessons from imaging studiesp. 125
Brain mapping of attention and neglect after strokep. 133
Depression and its effects after strokep. 145
Epidemiology of stroke recoveryp. 163
Treatment Strategies
Issues in clinical trial methodology for brain repair after strokep. 173
Neuropharmacology in stroke recoveryp. 183
Robotic approaches to stroke recoveryp. 195
Electromagnetic approaches to stroke recoveryp. 207
Intensive physical therapeutic approaches to stroke recoveryp. 219
Cognitive approaches to stroke recoveryp. 233
Electrical stimulation approaches to stroke recoveryp. 247
Growth factors as treatments for strokep. 259
Cellular approaches to stroke recoveryp. 267
Indexp. 275
Table of Contents provided by Ingram. All Rights Reserved.

ISBN: 9780521515337
ISBN-10: 0521515335
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 292
Published: 31st October 2010
Country of Publication: GB
Dimensions (cm): 24.64 x 18.8  x 2.03
Weight (kg): 0.82