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Brain Neurosecretory Cytokines : Immune Response and Neuronal Survival - Armen Galoyan

Brain Neurosecretory Cytokines

Immune Response and Neuronal Survival

Hardcover

Published: 30th April 2004
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Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival summarizes the biological and chemical data of signal molecules of the brain neuroendocrine immune system, mainly proline-rich peptides, which play an important role in the regulation of immune response, neuronal survival, hematopoiesis, and adaptation. The author also describes the role of PRPs for the protection of neurons against neurodegenerative disturbances and diseases.
Brain Neurosecretory Cytokines: Immune Response and Neuronal Survival will be of great aid to the researchers and students in various areas of neurobiological profile (neurochemistry, neuroendocrinology, neurophysiology, and endocrinology).

From the reviews:

"Brain Neurosecretory Cytokines is an excellent book, a veritable goldmine of information, at the cutting edge of neuroscience. It should stimulate ideas for future directions in neuroscience for years to come. This volume should be highly useful for medical libraries, neuroscientists, endocrinologists and graduate students in these fields." (Arthur S. Brecher, TRENDS in Endocrinology & Metabolism, Vol. 16 (6), 2005)

Neurosecretion of cytokines by N. paraventricularis and N. supraopticus of hypothalamusp. 5
The isolation of neurosecretory granules from bovine hypothalamus and neurohypophysis : bioassay methods of cytokine identificationp. 5
Identification of interleukins 1[alpha] and 1[beta] in the lysates of neurosecretory granules of bovine neurohypophysis and hypothalamusp. 6
Identification of IL-2 in the neurosecretory granules of bovine neurohypophysis and hypothalamusp. 8
Identification of IL-6 in the neurosecretory granules of bovine neurohypophysisp. 9
Identification of tumor necrosis factor [alpha] (TNF-[alpha]) in the neurosecretory granules of bovine hypothalamus and neurohypophysisp. 9
Discovery of new neurosecretory cytokines : prolinerich peptides produced by N. paraventricularis and N. supraopticus of hypothalamusp. 13
Isolation of proline-rich peptides from the neurosecretory granules of bovine neurohypophysis : primary structures, mass-spectral characteristics, and localizationp. 13
Identification of PRP-1 in the brain by immunohistochemical methods using polyclonal antibodiesp. 23
Determination of PRP-1 in the thymus, lymph nodes, and heart using monoclonal antibodiesp. 27
Interactions of PRP-1 with coagulation cascade components : a potential role for PRP-1 in the metabolism of factor Xa/antithrombin III complexp. 31
Interaction of PRP-1 with cytokines, hormones, and neurotransmittersp. 33
Effect of PRP-1 and lysates of neurosecretory granules on the expression of cytokines in macrophages and astrocytesp. 33
Effect of PRP-1 on the expression of interleukins and prolactin in different organs of mice during aluminum neurotoxicosisp. 37
PRP-1 increases the expression and release of human growth hormone in the culture of BALB/c mouse fibroblastsp. 40
Antibacterial and antiviral activity of PRP-1 and some immunological mechanisms of its actionp. 45
Effects of PRP-1 on the survival of mice infected with different strains of gram-negative and gram-positive bacteria at lethal dosesp. 46
Effects of PRP-1 on the growth of bacteria in the internal organs of mice infected with S. typhimuriump. 47
Effects of PRP-1 on anti-microbial antibody production in mice infected with S. typhimurium and S. cholerae suis in lethal dosesp. 47
Effect of PRP-1 on bactericidal activity of macrophagesp. 48
Effect of PRP-1 on the secretion of interleukin-1 by peritoneal macrophages of mice infected with S. typhimurium in sublethal dosesp. 48
Effect of PRP-1 on the antigen-presenting function of macrophages in mice infected with S. typhimuriump. 49
Effect of PRP-1 on the accumulation of macrophages in peritoneal cavities of mice infected with S. typhimuriump. 50
Effect of PRP-1 on the viability of macrophages in mice infected with S. typhimuriump. 50
Effect of PRP-1 on interferon-[gamma] (IFN-[gamma]) biosynthesis in human mononuclear cells and the replication of encephalomyocarditis virus in cell culturep. 53
PRP regulation of T-lymphocyte development and myelopoiesisp. 57
Influence of PRP-1 on interleukin-2-dependent functions of human lymphocytes in culture and on the proliferation of jurkat cellsp. 57
Regulation of thymocyte differentiation by PRP-1 in neonatal and fetal thymusp. 60
PRP-1 is a regulator of myelopoiesisp. 66
Neuroprotective (antineurodegenerative) properties of PRP-1p. 75
Protective effect of PRP-1 against snake venom-induced neuronal injuryp. 75
Protective effect of PRP-1 against trauma-induced central and peripheral neuronal injuryp. 93
Morphological and biochemical changes in brain microstructure in crush syndrome and effect of PRP-1p. 110
PRP-1 protects brain neurons against aluminum (Al) neurotoxicosis (electron microscopy studies)p. 118
Effect of PRP-1 on tumor cellsp. 129
Effect of PRP-1 on the morphology and mitotic activity of neurinoma of rat noduli gasser (NRNG) cells in culture (electron microscopy studies)p. 130
Changes in the ultrastructure of L[subscript 929] tumor cells under the action of PRP-1 in vitrop. 133
Basic biochemical mechanisms of PRP-1 action in different pathologiesp. 137
Effect of PRP-1 on GFAP biosynthesis in astrocyte culture (immunocytochemical data)p. 137
Effect of PRP-1 on caspase activity of murine neuroblastoma N2Ap. 140
Regulation of membrane phospholipid metabolism by PRP-1 in cardiopulmonary insufficiencyp. 144
Influence of PRP-1 on consequences of ionizing irradiation in ratsp. 153
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306483370
ISBN-10: 0306483378
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 188
Published: 30th April 2004
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 25.4 x 17.8  x 1.91
Weight (kg): 1.33